N-phthaloyl-glycine-hydroxamic acid as serum iron chelator in rats

Matijević-Sosa, Julija; Samaržija, Ita; Honović, Lorena; Jurišić, Blaženka

Pregled bibliografske jedinice broj: 348541

N-phthaloyl-glycine-hydroxamic acid as serum iron chelator in rats

Matijević-Sosa, Julija; Samaržija, Ita; Honović, Lorena; Jurišić, Blaženka

N-phthaloyl-glycine-hydroxamic acid as serum iron chelator in rats // Acta pharmaceutica, 58 (2008), 2; 231-236 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 348541 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
N-phthaloyl-glycine-hydroxamic acid as serum iron chelator in rats

Autori
Matijević-Sosa, Julija ; Samaržija, Ita ; Honović, Lorena ; Jurišić, Blaženka

Izvornik
Acta pharmaceutica (1330-0075) 58 (2008), 2; 231-236

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
N-phthaloyl-glycine-hydroxamic acid ; iron chelators ; iron overload

Sažetak
The aim of this study was to investigate the activity of N-phthaloyl-glycine-hydroxamic acid (Phth-Gly-HA) as a new chelator of iron in vivo to be used in iron overload diseases. After intraperitoneal application of Phth-Gly-HA to male rats (1 mg kg-1 body mass) once a day for seven days, iron serum level decreased by 21%, whereas in female rats (1.5 mg kg-1 body mass) the iron value dropped for 32%. Results indicate that the tested substance has the ability to bind serum iron by complexation. Besides transferrin iron release, mobilization of ferritin iron is also possible.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA

Projekti:
MZOS-006-0000000-0011 - Endokrina i parakrina regulacija renalnih transporta i nefrofarmakologija (Samaržija, Ita, MZOS ) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Lorena Honović (autor)