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Pregled bibliografske jedinice broj: 347265

Radioprotective effect of propolis and quercetin gamma-irradiated mice evaluated by the alkaline comet assay

Benković, Vesna; Horvat Knežević, Anica; Đikić, Domagoj; Lisičić, Duje; Oršolić, Nada; Bašić, Ivan; Kosalec, Ivan; Kopjar, Nevenka
Radioprotective effect of propolis and quercetin gamma-irradiated mice evaluated by the alkaline comet assay // Phytomedicine, 15 (2008), 10; 851-858 doi:10.1016/j.phymed.2008.02.010 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 347265 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Radioprotective effect of propolis and quercetin gamma-irradiated mice evaluated by the alkaline comet assay

Autori
Benković, Vesna ; Horvat Knežević, Anica ; Đikić, Domagoj ; Lisičić, Duje ; Oršolić, Nada ; Bašić, Ivan ; Kosalec, Ivan ; Kopjar, Nevenka

Izvornik
Phytomedicine (0944-7113) 15 (2008), 10; 851-858

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
alkaline comet assay; white blood cells; mice; propolis; quercetin; radioprotection

Sažetak
The radioprotective effects of ethanolic extract of propolis (EEP) and quercetin on the white blood cells of the whole-body irradiated CBA mice were investigated. Irradiation was performed using a γ -ray source (60Co), and absorbed dose was 9 Gy. The efficiency of test components was evaluated when given intraperitoneally (ip) at dose of 100 mg kg-1 for 3 consecutive days before and/or after irradiation. Moreover, possible genotoxic effects of test components were also assessed on non-irradiated animals. For each experimental group leukocyte count was determined and the primary DNA damage in leukocytes was assessed using the alkaline comet assay. The higher efficiency of EEP and quercetin was observed when given preventively. The results suggest that propolis and quercetin given to mice before irradiation protect their white blood cells from lethal effects of irradiation and diminish primary DNA damage as confirmed by the alkaline comet assay. Positive results obtained on gamma-irradiated mice given EEP and quercetin, complementary with our earlier observations on survival of irradiated mice ; indicate that these compounds could be considered effective non-toxic radioprotectors. The exact mechanisms of radioprotection by these compounds and their effects on DNA repair processes still are to be elucidated.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA

Projekti:
022-0222148-2137 - Genotoksičnost kemijskih i fizikalnih agensa prirodnog i antropogenog podrijetla (Kašuba, Vilena, MZOS ) ( CroRIS)
119-0000000-1255 - Kemoprevencija rasta tumora polifenolnim sastavnicama (Oršolić, Nada, MZOS ) ( CroRIS)
119-0532265-1254 - Imunoadjuvantno i zaštitno djelovanje propolisa u životinja (Benković, Vesna, MZOS ) ( CroRIS)
006-0061117-1242 - Mikromicete, interakcije toksičnih metabolita-zdravlje i prevencija (Šegvić Klarić, Maja, MZOS ) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Domagoj Đikić (autor)

Avatar Url Vesna Benković (autor)

Avatar Url Anica Horvat Knežević (autor)

Avatar Url Ivan Kosalec (autor)

Avatar Url Ivan Bašić (autor)

Avatar Url Duje Lisičić (autor)

Avatar Url Nevenka Kopjar (autor)

Avatar Url Nada Oršolić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com dx.doi.org dx.doi.org

Citiraj ovu publikaciju:

Benković, Vesna; Horvat Knežević, Anica; Đikić, Domagoj; Lisičić, Duje; Oršolić, Nada; Bašić, Ivan; Kosalec, Ivan; Kopjar, Nevenka
Radioprotective effect of propolis and quercetin gamma-irradiated mice evaluated by the alkaline comet assay // Phytomedicine, 15 (2008), 10; 851-858 doi:10.1016/j.phymed.2008.02.010 (međunarodna recenzija, članak, znanstveni)
Benković, V., Horvat Knežević, A., Đikić, D., Lisičić, D., Oršolić, N., Bašić, I., Kosalec, I. & Kopjar, N. (2008) Radioprotective effect of propolis and quercetin gamma-irradiated mice evaluated by the alkaline comet assay. Phytomedicine, 15 (10), 851-858 doi:10.1016/j.phymed.2008.02.010.
@article{article, author = {Benkovi\'{c}, Vesna and Horvat Kne\v{z}evi\'{c}, Anica and \DJiki\'{c}, Domagoj and Lisi\v{c}i\'{c}, Duje and Or\v{s}oli\'{c}, Nada and Ba\v{s}i\'{c}, Ivan and Kosalec, Ivan and Kopjar, Nevenka}, year = {2008}, pages = {851-858}, DOI = {10.1016/j.phymed.2008.02.010}, keywords = {alkaline comet assay, white blood cells, mice, propolis, quercetin, radioprotection}, journal = {Phytomedicine}, doi = {10.1016/j.phymed.2008.02.010}, volume = {15}, number = {10}, issn = {0944-7113}, title = {Radioprotective effect of propolis and quercetin gamma-irradiated mice evaluated by the alkaline comet assay}, keyword = {alkaline comet assay, white blood cells, mice, propolis, quercetin, radioprotection} }
@article{article, author = {Benkovi\'{c}, Vesna and Horvat Kne\v{z}evi\'{c}, Anica and \DJiki\'{c}, Domagoj and Lisi\v{c}i\'{c}, Duje and Or\v{s}oli\'{c}, Nada and Ba\v{s}i\'{c}, Ivan and Kosalec, Ivan and Kopjar, Nevenka}, year = {2008}, pages = {851-858}, DOI = {10.1016/j.phymed.2008.02.010}, keywords = {alkaline comet assay, white blood cells, mice, propolis, quercetin, radioprotection}, journal = {Phytomedicine}, doi = {10.1016/j.phymed.2008.02.010}, volume = {15}, number = {10}, issn = {0944-7113}, title = {Radioprotective effect of propolis and quercetin gamma-irradiated mice evaluated by the alkaline comet assay}, keyword = {alkaline comet assay, white blood cells, mice, propolis, quercetin, radioprotection} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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