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Pregled bibliografske jedinice broj: 347202

Evaluation of radioprotective effects of propolis and flavonoids in gamma-irradiated mice : the alkaline comet assay study

Benković, Vesna; Oršolić, Nada; Horvat Knežević, Anica; Ramić, Snježana; Đikić, Domagoj; Bašić, Ivan; Kopjar, Nevenka
Evaluation of radioprotective effects of propolis and flavonoids in gamma-irradiated mice : the alkaline comet assay study // Biological & pharmaceutical bulletin, 31 (2008), 1; 167-172 doi:10.1248/bpb.31.167 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 347202 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Evaluation of radioprotective effects of propolis and flavonoids in gamma-irradiated mice : the alkaline comet assay study

Autori
Benković, Vesna ; Oršolić, Nada ; Horvat Knežević, Anica ; Ramić, Snježana ; Đikić, Domagoj ; Bašić, Ivan ; Kopjar, Nevenka

Izvornik
Biological & pharmaceutical bulletin (0918-6158) 31 (2008), 1; 167-172

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
radioprotection; propolis; flavonoids; mice; alkaline comet assay

Sažetak
The radioprotective effects of water-soluble derivate of propolis (WSDP) collected in Croatia, and single flavonoids caffeic acid, chrysin and naringin in the whole-body irradiated CBA mice were investigated. Irradiation was performed using a γ -ray source (60Co), and absorbed doses were 4 and 9 Gy. The efficiency of test components was evaluated when given intraperitoneally (ip) at dose of 100 mg kg-1 for 3 consecutive days before and/or after irradiation. Moreover, possible genotoxic effects of all test components were assessed on non-irradiated animals. The higher efficiency of test components was observed when given preventively. The results suggest that propolis and related flavonoids given to mice before irradiation protect mice from lethal effects of whole-body irradiation and diminish primary DNA damage in their white blood cells as detected by the alkaline comet assay and micronucleus assay.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA

Projekti:
022-0222148-2137 - Genotoksičnost kemijskih i fizikalnih agensa prirodnog i antropogenog podrijetla (Kašuba, Vilena, MZOS ) ( CroRIS)
119-0532265
119-0000000-1255 - Kemoprevencija rasta tumora polifenolnim sastavnicama (Oršolić, Nada, MZOS ) ( CroRIS)
119-0532265-1254 - Imunoadjuvantno i zaštitno djelovanje propolisa u životinja (Benković, Vesna, MZOS ) ( CroRIS)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Klinika za tumore,
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Snježana Ramić (autor)

Avatar Url Domagoj Đikić (autor)

Avatar Url Vesna Benković (autor)

Avatar Url Ivan Bašić (autor)

Avatar Url Anica Horvat Knežević (autor)

Avatar Url Nevenka Kopjar (autor)

Avatar Url Nada Oršolić (autor)

Poveznice na cjeloviti tekst rada:

doi www.jstage.jst.go.jp www.jstage.jst.go.jp dx.doi.org

Citiraj ovu publikaciju:

Benković, Vesna; Oršolić, Nada; Horvat Knežević, Anica; Ramić, Snježana; Đikić, Domagoj; Bašić, Ivan; Kopjar, Nevenka
Evaluation of radioprotective effects of propolis and flavonoids in gamma-irradiated mice : the alkaline comet assay study // Biological & pharmaceutical bulletin, 31 (2008), 1; 167-172 doi:10.1248/bpb.31.167 (međunarodna recenzija, članak, znanstveni)
Benković, V., Oršolić, N., Horvat Knežević, A., Ramić, S., Đikić, D., Bašić, I. & Kopjar, N. (2008) Evaluation of radioprotective effects of propolis and flavonoids in gamma-irradiated mice : the alkaline comet assay study. Biological & pharmaceutical bulletin, 31 (1), 167-172 doi:10.1248/bpb.31.167.
@article{article, author = {Benkovi\'{c}, Vesna and Or\v{s}oli\'{c}, Nada and Horvat Kne\v{z}evi\'{c}, Anica and Rami\'{c}, Snje\v{z}ana and \DJiki\'{c}, Domagoj and Ba\v{s}i\'{c}, Ivan and Kopjar, Nevenka}, year = {2008}, pages = {167-172}, DOI = {10.1248/bpb.31.167}, keywords = {radioprotection, propolis, flavonoids, mice, alkaline comet assay}, journal = {Biological and pharmaceutical bulletin}, doi = {10.1248/bpb.31.167}, volume = {31}, number = {1}, issn = {0918-6158}, title = {Evaluation of radioprotective effects of propolis and flavonoids in gamma-irradiated mice : the alkaline comet assay study}, keyword = {radioprotection, propolis, flavonoids, mice, alkaline comet assay} }
@article{article, author = {Benkovi\'{c}, Vesna and Or\v{s}oli\'{c}, Nada and Horvat Kne\v{z}evi\'{c}, Anica and Rami\'{c}, Snje\v{z}ana and \DJiki\'{c}, Domagoj and Ba\v{s}i\'{c}, Ivan and Kopjar, Nevenka}, year = {2008}, pages = {167-172}, DOI = {10.1248/bpb.31.167}, keywords = {radioprotection, propolis, flavonoids, mice, alkaline comet assay}, journal = {Biological and pharmaceutical bulletin}, doi = {10.1248/bpb.31.167}, volume = {31}, number = {1}, issn = {0918-6158}, title = {Evaluation of radioprotective effects of propolis and flavonoids in gamma-irradiated mice : the alkaline comet assay study}, keyword = {radioprotection, propolis, flavonoids, mice, alkaline comet assay} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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