Naslov
Propolis and related flavonoids as radioprotective agents

Autori
Oršolić, Nada ; Benković, Vesna ; Horvat-Knežević, Anica ; Bašić Ivan

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Herbal Radiomodulators : Applications in Medicine, Homeland Defence and Space

Urednik/ci
Rajesh Arora

Izdavač
CABI Publishing

Grad
Wallingford

Godina
2008

Raspon stranica
175-194

ISBN
9781845933951

Ključne riječi
propolis, radioprotection, flavonoids, polyphenolic compounds,

Sažetak
Dietary factors play an important role in human health and in the development of certain chronic diseases including cancer. Polyphenolic compounds are widely distributed in the plant kingdom and display a variety of biological activities, including the free radical scavenging ability, tissue regeneration properties, immunostimulatory effects, chemoprevention and growth inhibition of tumors. It has been well established that biological effects of radiation result from energy deposition in irradiated cells in which reactive oxygen species (ROS), including superoxide anion (O2• ─ ), hydroxyl radical (OH• ) and hydrogen peroxide (H2O2) are produced. However, if overproduction of ROS occurs, oxidative damage can lead to radiation-induced cytotoxicity (chromosomal damage and mutations) or lethality. It is also widely believed that oxidative damage contributes significantly to the development of age-related chronic illness such as cancer and degenerative diseas. For these reasons, the search for new radioprotectors that are less toxic than the currently available compounds is crucially needed to develop better strategies for protecting exposed populations from radiation injury.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti

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