Naslov
Telomere dynamics : the means to an end

Autori
Matulić, Maja ; Sopta, Mary ; Rubelj, Ivica

Izvornik
Cell proliferation (0960-7722) 40 (2007), 4; 462-474

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
telomere dynamics

Sažetak
Telomeres are among the most important structures in eukaryotic cells. Creating the physical ends of linear chromosomes, they play a crucial role in maintaining genome stability, control of cell division, cell growth and senescence. In vertebrates, telomeres consist of G-rich repetitive DNA sequences (TTAGGG)n and specific proteins, creating a specialized structure called the telosome that through mutual interactions with many other factors in the cell give rise to dynamic regulation of chromosome maintenance. In this review, we survey the structural and mechanistic aspects of telomere length regulation and how these processes lead to alterations in normal and immortal cell growth.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA