ࡱ> .0)*+,-ec@ bjbjFF .@,,=@@@@   222l3 =lRo:>LL>@>>>@A\A0iiiiiii$pRr#j D@"@DD#j@@>> obObObODz@> >ibODibObOR@ )R>= T,}2G2Rh"o0Ro!RsBL s)R@@@@s )R-BhBJbOB<C{-B-B-B#j#jh"$NMh"FULL PAPER DOI: 10.1002/ejoc.200((will be filled in by the editorial sttaff)) Synthesis of Mannose and Galactose Conjugates with 1-Adamantamine Rosana Golub, }eljka Car, Vesna Petrovi, and Sranka Tomi* Keywords: Mannose / Galactose / Chiral linker / O-Glycoside / 1-Adamantamine Compounds that contain the sugar moiety (mannose, galactose) connected to 1-adamantamine (AMA) by a chiral linker (methyl (R)-3-hydroxy-2-methyl propionate or methyl (S)-3-hydroxy-2-methyl propionate) were prepared and identified. The trichloroacetimidate method was used to obtain the O-glycosidic bond between the monosaccharide unit and the hydroxyl group of the chain linker. Thus, pure - and -anomers of O-mannopyranoside and O-galactopyranoside were prepared. Basic ester hydrolysis liberated the carboxyl group which was then activated and coupled with AMA using EDC/HOBt. The final step was the deprotection of the sugar part to give novel derivatives of AMA. Adamantane containing compounds generally exhibit various biological activities. Therefore, it is resonable to expect that these novel derivatives will display some biological activities, as well. ( WILEY-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007) ____________ Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, HR-10000 Zagreb, Croatia Fax: +385-1-460-6401 Tel: +385-1-460-6411 E-mail: stomic@chem.pmf.hr Introduction Research in the field of molecular biology has shown that carbohydrates play many important roles in molecular recognition processes. Some specific monosaccharidic units (mannose, galactose, N-acetylglucosamine, N-acetylgalactosamine, L-fucose or N-acetylneuraminic acid) incorporated in oligosaccharides or glycoconjugates are recognized by lectins, cell proteins which specifically and reversibly bind sugar containing structures.[1,2] The elucidation of the recognition processes has as yet only just begun. Some of the most important tasks of glycobiology are to explore the structures of saccharides and receptors involved in molecular recognition, to discover the details of carbohydrate-receptor interactions on the molecular level and to find out the biological role which then leads to the possible therapeutical application of saccharide containing structures. Chemical synthesis has become a crucial tool in providing model glycosides and saccharides which can be used in the elucidation of carbohydrate recognition processes.[3] It is highly possible that some of the prepared model molecules will eventually be used in therapeutical applications. Compounds containing the adamantyl structure are known as sedatives[4], antitumor agents[5], antibiotics[6], hypoglycemics[7], antidepressants[8], drugs in the therapy of Parkinson's disease[9], etc. Our interest as described in this work has been focused on the preparation of novel glycoconjugates containing 1- adamantamine (AMA). Amantadine (AMAxHCl) and its derivatives are biologically active and were, up to now, mostly used in the therapy of viral diseases[10]. It is especially effective in the prophylaxis and treatment of influenza A infections.[11] Glycoconjugates of AMA, the syntheses of which are described in this work, contain mannose or galactose residues, some of the monosaccharides which are specifically recognized by lectins. It is to be expected that some of these compounds and especially their multivalent derivatives might be bioactive. Thus, we explored firstly the synthesis of O-mannosyl and O-galactosyl derivatives of AMA using O-glycosidically bonded unnatural chiral linkers which facilitate the sugar-AMA connection. Results and Discussion The O-glycosidic connection of monosaccharides with the hydroxyl group of chiral chain hydroxyesters was the first step in obtaining sugar-modified AMA derivatives. This resulted with the introduction of a carboxyl group chosen as a function for the coupling with AMA. Schemes 1 and 2 show the reaction sequence starting from methyl--D-mannopyranoside 1 and methyl--D-glactopyranoside 2 to the key intermediates 9-12 used for the synthesis of mannose and galactose conjugates with AMA. The first step was the protection of sugar hydroxyl groups with benzyls using classical conditions of the Williamson synthesis. Compound 1 was benzylated using BnCl/KOH[12] and 2 using BnBr/NaH[13]. For the synthesis of compound 4 combination of stronger base and better benzyl donor was used because of the problematic reactivity of 4-OH group in 2.[14] Benzyl ethers are widely used protecting groups in carbohydrate chemistry because they are particularly stable, resistant to strong basic or acidic conditions. Furthermore, it is known that the synthesis of 1,2-cis glycosides, such as -mannosides and -galactosides, is much more difficult than the 1,2-trans glycosidation when participating protecting groups, such as esters, are at the C-2 position. A prerequisite for the preparation of 1,2-cis glycosides is the use of C-2 non-participating group. Ether-type protecting groups, such as the O-benzyl group in our case, have a low tendency to participate and are, therefore, commonly used for this purpose.[15] This was of importance since we aimed to obtain the final glycoside products (21-24) in both anomeric forms. The selective removal of the anomeric methyl group followed. Since methyl glycosides are among the most stable glycosides, forced acid-catalyzed reaction conditions were required for the cleavage (acetolysis - a mixture of acetic and sulphuric acid).[16] / Ratio was determined from intensities for anomeric protons in the 1H NMR spectra, and were as follows: 5/5 = 1/0.4, 6/6 = 1/0.7. Benzylated reducing sugars 5 and 6 were then transformed into good glycosyl donors using the trichloroacetimidate method.[17] Trichloroacetimidates 7 and 8 were prepared in the base-treated (NaH) reactions with trichloroacetonitrile at 0C in dichloromethane.[16] O-mannosylation and O-galactosylation of methyl (R)-(")- and (S)-(+)-3-hydroxy-2-methylpropionates was promoted by the catalytic amount of boron trifluoride diethyl etherate (BF3xEt2O) in dichloromethane at 0C. These trichloroacetimidate-mediated O-glycosylations gave anomeric mixtures of the corresponding O-glycosides 9-12 (61-73%). / Ratio for O-mannosides 9 and 11 were found to be 3 : 1 and for O-galactosides 10 and 12 2 : 1. Since the non-participating protecting group was at the C-2 positions, SN2-type reaction could occur leading to the -anomers. Such inversion was also assisted by the use of lower temperatures and weak Lewis acid catalyst. On the other hand, the -mannosides and the -galactosides are thermodynamically more stable glycosylation products because of the strong anomeric effect. Anomers of compounds 9-12 were relatively easily separated by column chromatography on silica gel. Pure anomers of each O-glycoside 9-12 and 9-12 were obtained in moderate overall yields. The hydrolysis of the methyl ester of each anomer 9-12 (77-94%) was performed by saponification using 1M sodium hydroxide in dioxane. Next step was activation of a free carboxyl group and condensation with AMA. To achieve the most efficient procedure, several methods were previously explored (Sheme 3). The first approach was the preparation of an active N-hydroxysuccinimide ester (HOSu) 25 as good acylating agent for the reaction with AMA using the conventional procedure.[18] Condensation of the AMA with the ester 25 gave the glycoconjugate 17 in 78% yield. The pentafluorophenyl ester was also prepared in the same way in 88% yield but the condensation with AMA this time failed. A two-step synthesis with smaller overall yield is the main disadvantage of this method. Second, favored strategy, includes carbodiimide-mediated synthesis based on in situ activation of carboxyl carbon and amide bond formation using DCC/HOBt[19], DCC/DMAP[20] or EDCHCl/HOBt. Both, DCC- and EDC-mediated coupling reactions gave the desired product 17. The activation with EDCHCl as a coupling reagent is a better method because the by-product, a water-soluble urea, can be easily removed by extraction. N,N-Dicyclohexylurea contaminates reaction products because of its solubility in water as well as in most organic solvents. Therefore, EDCHCl/HOBt procedure was chosen for the condensation with AMA. Glycoconjugates 17-20 were obtained in good yields (55-66%) in just one step starting from corresponding acids 13-16. Debenzylation of compounds 17-20 gave the desired mannose and galactose AMA conjugates 21-24 in excellent yields (87-95%). Benzyl deprotection was performed by classic hydrogenolysis with 10% Pd on charcoal in methanol.  EMBED ChemDraw.Document.6.0  Scheme 1. Preparation of trichloroacetimidate derivatives and glycosylation procedure: a) KOH, dry dioxan, 1, BnCl, 100 C, 3h; b) 1) NaH, dry DMF, 2, 0 C, N2, 2h; 2) KI, BnBr, rt, 24h; c) CH3COOH, H2SO4 (3M), 70 C, 24h; d) NaH, Cl3CCN, dry DCM, 0 C, 2.5h; e) methyl (R)-3-hydroxy-2-methyl propionate or methyl (S)-3-hydroxy-2-methyl propionate, BF3xEt2O, dry DCM, 0 C, N2, 2.5h.  EMBED ChemDraw.Document.6.0  Scheme 2. Synthesis of protected and deprotected AMA conjugates: a) NaOH (1M), dioxan, 40 C, 24h; b) 1) EDCxHCl, Et3N, dry DCM, 0 C, 0.5h; 2) HOBt, 0 C, 2h; 3) AMAxHCl, Et3N, rt, 24h; c) H2 (4 bar), Pd/C (10%), MeOH, rt, 24h.  EMBED ChemDraw.Document.6.0  Scheme 3. Alternative pathways for amide bond formation: a) 1) DCC, HOBt, AMAxHCl, Et3N, rt, 24h (78%) or 2) DCC, DMAP, AMAxHCl, N-ethylmorpholine, rt, 24h (67%); b) EDCxHCl, HOSu, dry DCM, rt, 24h (78%); c) AMAxHCl, Et3N, rt, 24h (83%). Conclusions The synthesis of novel mannose and galactose conjugates with AMA has been reported. O-Mannosides 9, 10 and O-galactosides 11, 12 were prepared by trichloroacetimidate-mediated glycosylation. Corresponding pure - and -anomers were obtained using column chromatography, the simplest conventional separation method. Carboxy-functionalized glycosides 13-16 were coupled with AMA employing the EDCHCl/HOBt procedure and glycoconjugates 17-20 were obtained. The investigation of the biological activities of prepared compounds is in progress. We are currently extending our studies on the preparation of multivalent derivatives on the basis of the results that have been reported here. Experimental Section Starting compounds methyl -D-mannopyranoside (1) and methyl -D-galactopyranoside (2) were purchased from Fluka. Most of the chemical reagents used in syntheses were obtained also from Fluka and Aldrich Corp. All solvents were purified using standard procedures. Column cromatography (solvents and proportions are given in the text) was performed on Merck silica gel 60 (size 70-230 mesh ASTM) and TLC monitoring on Fluka silica gel (60 F 254) plates (0.25 mm). Visualization was effected mostly by use of UV light and/or by charring with H2SO4. Optical rotations were measured at room temperature using the Schmidt + Haensch Polartronic NH8. NMR spectra were recorded using Bruker Avance (300 MHz) spectrometer. Methyl 2,3,4,6-tetra-O-benzyl--D-mannopyranoside (3): To a suspension of 1 (5 g, 25.9 mmol) in dry dioxan (40 mL) KOH (25.3 g, 0.45 mol, 17.5 equiv) was added. BnCl (25 mL, 0.22 mol, 8.5 equiv) was than added dropwise. The reaction mixture was stirred at 100C for 3 h and monitored by TLC (2:1 C6H6/EtOAc). The mixture was than filtered and the filtrate distilled. After steam distillation, the mixture was extracted with chloroform. Organic layer was dried over Na2SO4. After filtration, the organic layer was concentrated in vacuo and the residue was purified by column chromatography on silica gel (2:1 C6H6/EtOAc). The product 3 was isolated as yellow oil (10.6 g, 78 %); Rf (2:1 C6H6/AcOEt)=0.74; []D +24.7 (c 0.55, CHCl3). 3: 1H NMR (300 MHz, DMSO):  = 7.38-7.19 (m, 20 H, H Ar), 4.81 (s, 1 H, H-1), 4.79-4.47 (m, 8 H, 4 CH2Ph), 3.88 (br s, 1 H, H-2), 3.77 (app t, J = 9.37 Hz, J = 9.48 Hz, 1 H, H-4), 3.73 (dd, J2, 3 = 2.84 Hz, J3, 4 = 9.30 Hz, 1 H, H-3), 3.68-3.63 (m, 2 H, H-6a, H-6b), 3.57-3.54 (m, 1 H, H-5), 3.27 (s, 3 H, OCH3) ppm. 13C NMR (300 MHz, CDCl3):  = 138.44, 138.35, 138.29, 138.19 (4 C Ar), 128.33-127.29 (CH Ar), 98.90 (C1), 80.15, 74.85, 74.55, 71.64 (C2-C5), 74.94, 73.26, 72.51, 72.02 (4 CH2Ph), 69.27 (C6) and 54.59 (OCH3) ppm. Methyl 2,3,4,6-tetra-O-benzyl--D-galactopyranoside (4): To a solution of NaH (2.47 g of 60 % in mineral oil, 1.5 g of NaH, 61.8 mmol, 6 equiv) in dry DMF (7 mL) at 0C under N2 4 (2.0 g, 10.3 mmol) was added gradually over 20 min. The reaction mixture was then stirred at room temperature for 2 h. KI (0.17 g, 1.0 mmol, 0.1 equiv) was added next followed by slow addition of BnBr (5.5 mL, 7.9 g, 46.4 mmol, 4.5 equiv). The reaction mixture was then stirred for additional 24 h and monitored by TLC (10:1 C6H6/EtOAc). The mixture was then triturated with diethyl ether, the organic layer washed with water and saturated brine excessively, then dried over Na2SO4. After filtration, the organic layer was concentrated in vacuo and the residue was purified by column chromatography on silica gel (10:1 C6H6/EtOAc). 4 was isolated as yellow oil (3.99 g, 70 %); Rf (10:1 C6H6/EtOAc)=0.57; []D +10.7 (c 1.61, CHCl3). 4: 1H NMR (300 MHz, CDCl3):  = 7.38-7.27 (m, 20 H, H Ar), 4.94 (d, Jgem = 11.47 Hz, 1 H, CH2Ph), 4.86-4.66 (m, 4 H, 2 CH2Ph), 4.68 (d, J1, 2 = 3.61 Hz, 1 H, H-1), 4.57 (d, Jgem = 11.48 Hz, 1 H, CH2Ph), 4.49-4.37 (m, 2 H, CH2Ph), 4.06-4.01 (m, 1 H, H-2), 3.94-3.87 (m, 3 H, H-3, H-4, H-5), 3.60-3.51 (m, 2 H, H-6a, H-6b), 3.36 (s, 3 H, OCH3) ppm. 13C NMR (300 MHz, CDCl3):  = 138.77, 138.59, 138.46, 137.93 (4 C Ar), 128.43-127.31 (CH Ar), 98.74 (C1), 79.05, 76.40, 75.13, 69.18 (C2-C5), 74.67, 73.50, 73.42, 73.22 (4 CH2Ph), 69.03 (C6), 55.28 (OCH3) ppm. General procedure for anomeric demethylation of benzyl protected O-glycosides: To 3 or 4 (1.5 g, 2.7 mmol) 7.45 mL of CH3COOH and 2.35 mL of 3 M H2SO4 was added. The mixture was stirred under reflux at 70 C for 24 h and monitored by TLC (2:1 C6H6/EtOAc). Then 10 mL of cold water was added and the aqueous layer was extracted with diethyl ether. The combined organic layers were washed once with saturated NaHCO3 solution and again with water and dried over Na2SO4. After filtration, the organic layer was concentrated in vacuo and the residue purified by column chromatography on silica gel (2:1 C6H6/EtOAc) to obtain compounds (5,5) and (6,6) respectively. 2,3,4,6-Tetra-O-benzyl-D-mannopyranose (5,5): Yellow oil (1.00 g, 69 %); Rf (2:1 C6H6/EtOAct)=0.50; 5/5 = 1/0.4. 5: 1H NMR (300 MHz, CDCl3):  = 7.37-7.15 (m, 20 H, H Ar), 5.24 (s, 1 H, H-1), 4.88 (d, Jgem = 10.87 Hz, 1 H, CH2Ph), 4.75-4.52 (m, 6 H, 3 CH2Ph), 4.49 (d, Jgem = 10.86 Hz, 1 H, CH2Ph), 4.05-4.02 (m, 1 H, H-2), 3.96 (dd, J2, 3 = 2.75 Hz, J3, 4 = 9.06 Hz, 1 H, H-3), 3.85 (app t, J = 9.61 Hz, J = 10.16 Hz, 1 H, H-4), 3.73-3.65 (m, 3 H, H-5, H-6a, H-6b) ppm. 13C NMR (300 MHz, CDCl3):  = 138.49, 138.41, 138.36, 138.07 (4 C Ar), 128.53-127.50 (CH Ar), 92.79 (C1), 79.73, 75.23, 74.95, 7.66 (C2 C5), 75.00, 73.34, 72.71, 72.20 (4 CH2Ph), 69.69 (C6) ppm. 5: 1H NMR (300 MHz, CDCl3):  = 4.64 (s, 1 H, H-1) ppm. 13C NMR (300 MHz, CDCl3):  = 138.22, 138.19, 138.15, 138.02 (4 C Ar), 128.53-127.50 (CH Ar), 93.74 (C1), 83.06, 76.19, 75.27, 74.61 (C2-C5), 75.00, 74.65, 73.54, 72.84 (4 CH2Ph), 69.14 (C6) ppm. 2,3,4,6-Tetra-O-benzyl-D-galactopyranose (6,6): Pale yellow oil (0.76 g, 52 %); Rf (2:1 C6H6/EtOAc)=0.63; 6/6 = 1/0.7. 6: 1H NMR (300 MHz, CDCl3):  = 7.33-7.25 (m, 20 H, H Ar), 5.25 (d, J1, 2 = 3.49 Hz, 1 H, H-1), 4.91 (d, Jgem = 11.50 Hz, 1 H, CH2Ph), 4.80-4.69 (m, 4 H, 2 CH2Ph), 4.55 (d, Jgem = 11.52 Hz, 1 H, CH2Ph), 4.47-4.34 (m, 2 H, CH2Ph), 4.15 (app t, J = 6.34 Hz, J = 5.88 Hz, 1 H, H-5), 4.04-3.99 (m, 1 H, H-2), 3.93-3.90 (m, 2 H, H-3, H-4), 3.58-3.40 (m, 2 H, H-6a, H-6b) ppm. 13C NMR (300 MHz, CDCl3):  = 138.56, 138.44, 138.17, 137.69 (4 C Ar), 128.41-127.29 (CH Ar), 91.72 (C1), 78.62, 76.45, 74.71, 69.31 (C2-C5), 74.55, 73.34, 73.28, 72.86 (4 CH2Ph), 69.05 (C6) ppm. 6: 1H NMR (300 MHz, CDCl3):  = 4.61 (d, J1, 2 = 7.5 Hz, 1 H, H-1) ppm. 13C NMR (300 MHz, CDCl3):  = 138.56, 138.36, 138.31, 137.61 (4 C Ar), 128.41-127.29 (CH Ar), 97.69 (C1), 82.07, 80.62, 73.53, 69.31 (C2-C5), 74.98, 74.44, 73.40, 72.86 (4 CH2Ph), 68.82 (C6) ppm. General procedure for the preparation of glycosyl trichloroacetimidates: 5,5 or 6,6 (1 g, 1.85 mmol) was suspended in dry DCM (5 mL). Trichloroacetonitrile (927.8 L, 9.25 mmol, 5 equiv) and NaH (66.6 mg of 60 % in mineral oil, 111 mg of NaH, 2.78 mmol, 1.5 equiv) were added next. The mixture was stirred at 0 C for 2.5 h and monitored by TLC (1:1 diethyl ether/petroleum ether). The mixture was then filtered over a celite bed and the filtrate evaporated in vacuo. Flash column chromatography (1:1 diethyl ether/petroleum ether) gave the desired trichloroacetimidates (7,7) and (8,8). 2,3,4,6-Tetra-O-benzyl-D-mannopyranosyl trichloroacetimidate (7,7): Yellow oil (0.82 g, 65%); Rf (1:1 diethyl ether/petroleum ether)=0.73. 7: 1H NMR (300 MHz, CDCl3):  = 8.52 (s, 1 H, N H), 7.43-7.18 (m, 20 H, H Ar), 6.37 (d, J1, 2 = 1.78 Hz, 1 H, H-1), 4.92-4.48 (m, 8 H, 4 CH2Ph), 4.16 (app t, J = 9.61 Hz, J = 9.64 Hz, 1 H, H-4), 3.93 (dd, J2, 3 = 3.03 Hz, J3, 4 = 9.40 Hz, 1 H, H-3), 3.99-3.80 (m, 3 H, H-2, H-5, H-6a), 3.73 (dd, J5, 6b = 1.62 Hz, J6a, 6b = 11.16 Hz, 1 H, H-6b) ppm. 13C NMR (300 MHz, CDCl3):  = 160.46 (C=NH), 138.37, 138.30, 138.18, 138.00 (4 C Ar), 128.45-127.37 (CH Ar), 96.17 (C1), 78.96, 74.89, 74.26, 73.62 (C2-C5), 75.31, 73.39, 72.66, 72.35 (4 CH2Ph), 68.83 (C6) ppm. 7-Anomer was found in traces. 2,3,4,6-Tetra-O-benzyl-D-galactopyranosyl trichloroacetimidate (8,8): Yellow oil (0.82 g, 65 %); Rf (1:1 diethyl ether/petroleum ether)=0.60. 8: 1H NMR (300 MHz, CDCl3):  = 10.66 (brs, 1 H, N H), 7.35-7.25 (m, 20 H, H Ar), 6.52 (m, J1, 2 = 3.41 Hz, 1 H, H-1), 4.97 (d, Jgem = 11.32 Hz, 1 H, CH2Ph), 4.84-4.73 (m, 4 H, 2 CH2Ph), 4.59 (d, Jgem = 11.32 Hz, 1 H, CH2Ph), 4.48-4.38 (m, 2 H, CH2Ph), 4.24 (dd, J1, 2 = 3.43 Hz, J2,3 = 9.86 Hz, 1 H, H-2), 4.16 (appt, J = 6.28, J = 6.89, 1 H, H-5), 4.10-4.00 (m, 2 H, H-3, H-4), 3.64-3.52 (m, 2 H, H-6a, H-6b) ppm. 13C NMR (300 MHz, CDCl3):  = 161.24 (C=NH), 138.50, 138.47, 138.38, 137.80 (4 C Ar), 128.40-127.38 (CH Ar), 95.16 (C1), 77.90, 75.87, 74.61, 72.15 (C2-C5), 74.92, 73.43, 72.97, 72.90 (4 CH2Ph), 68.27 (C6) ppm. 8-Anomer was found in traces. General procedure for glycosylation of methyl (R)- and (S)-3-hydroxy-2-methylpropionates: Methyl (R)- or (S)-3-hydroxy-2-methylpropionate (151.07 L, 1.37 mmol, 1.6 equiv) was suspended in dry DCM (2 mL) at 0C under N2 and BF3xEt2O was added (277.52 L, 2.19 mmol, 1 equiv). Glycosyl trichloroacetimidate derivative 7,7 or 8,8 (1.5 g, 2.19 mmol) suspended in dry DCM (2 mL) was then added dropwise within 15 min after which the reaction mixture was stirred for the additional 2.5 h and monitored by TLC (1:1 diethyl ether/petroleum ether). Iced 1 M NaHCO3 was added and the resulting mixture extracted with diethyl ether. Organic layers were washed with water and dried over Na2SO4. After filtration, the organic layer was concentrated in vacuo and the residue was purified by column chromatography on silica gel (1:1 diethyl ether/petroleum ether). The products were isolated as anomeric pale yellow oil mixtures (9,9) (1023 mg, 73 %; Anal. Calcd. for C39H44O8 (Mr = 640.76): C 73.10, H 6.92 %; found: C 72.91, H 6.84 %), (10,10) (856 mg, 61 %; Anal. Calcd. for C39H44O8 (Mr = 640.76): C 73.10, H 6.92 %; found: C 72.88, H 6.88 %), (11,11) (953 mg, 68 %; Anal. Calcd. for C39H44O8 (Mr = 640.76): C 73.10, H 6.92 %; found: C 72.96, H 6.88 %) and (12,12) (912 mg, 65 %; Anal. Calcd. for C39H44O8 (Mr = 640.76): C 73.10, H 6.92 %; found: C 72.90, H 6.86 %). The anomeric mixtures were then rechromatographied to isolate pure anomers of each derivative. Methyl (R)-(-)-(2,3,4,6-tetra-O-benzyl--D-mannopyranosyloxy)-2-methylpropionate (9): Rf (1:1 diethyl ether/petroleum ether)=0.38; []D +17.3 (c 0.62, CHCl3). 1H NMR (300 MHz, CDCl3):  = 7.37-7.16 (m, 20 H, H Ar), 4.86 (d, Jgem = 10.38 Hz, 1 H, CH2Ph), 4.85 (s, 1 H, H-1), 4.74-4.53 (m, 6 H, 3 CH2Ph), 4.50 (d, Jgem = 10.79 Hz, 1 H, CH2Ph), 3.97 (app t, J = 9.38 Hz, J = 9.41 Hz, 1 H, H-4), 3.84 (dd, J2, 3 = 2.96 Hz, J3,4 = 9.33 Hz, 1 H, H-3), 3.77 (dd, J5, 6a = 5.50 Hz, J6a, 6b = 11.14 Hz, 1 H, H-6a), 3.73-3.68 (m, 4 H, OCH2, H-2, H-6b), 3.64 (s, 3 H, OCH3), 3.59-3.56 (m, 1 H, H-5), 2.72-2.66 (m, 1 H, CH), 1.12 (d, J = 7.15 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CDCl3):  = 174.85 (C=O), 138.52, 138.52, 138.47, 138.39 (4 C Ar), 128.40-127.31 (CH Ar), 98.36 (C1), 80.08, 74.92, 74.84, 72.16 (C2-C5), 75.03, 73.36, 72.61, 72.22 (4 CH2Ph), 69.35 (C6), 69.33 (OCH2), 51.63 (OCH3), 39.96 (CH), 13.97 (CH3) ppm. Methyl (R)-(-)-(2,3,4,6-tetra-O-benzyl--D-mannopyranosyloxy)-2-methylpropionate (9): Rf (1:1 diethyl ether/petroleum ether)=0.28; []D -39.3 (c 0.51, CHCl3). 1H NMR (300 MHz, CDCl3):  = 7.45-7.18 (m, 20 H, H Ar), 4.95 (d, Jgem = 12.49 Hz, 1 H, CH2Ph), 4.90 (d, Jgem = 10.74 Hz, 1 H, CH2Ph), 4.81 (d, Jgem = 12.43 Hz, 1 H, CH2Ph), 4.53 (d, Jgem = 10.65 Hz, 1 H, CH2Ph), 4.65-4.42 (m, 4 H, 2 CH2Ph), 4.39 (s, 1 H, H-1), 4.16-4.14 (m, 1 H, H-4), 3.88-3.79 (m, 2 H, H-2, H-3), 3.76-3.71 (m, 2 H, OCH2), 3.66 (s, 3 H, OCH3), 3.59-3.56 (m, 1H, H-6a), 3.50-3.48 (m, 1 H, H-6b), 3.45-3.43 (m, 1 H, H-5), 2.84-2.80 (m, 1 H, CH), 1.24 (d, J = 6.95 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CDCl3):  = 174.72 (C=O), 138.77, 138.51, 138.38, 138.19 (4 C Ar), 128.40-127.31 (CH Ar), 101.85 (C1), 82.27, 76.09, 74.89, 73.62 (C2-C5), 75.13, 73.70, 73.47, 71.44 (4 CH2Ph), 71.37 (C6), 69.62 (OCH2), 51.70 (OCH3), 40.09 (CH), 13.93 (CH3) ppm. Methyl (S)-(+)-(2,3,4,6-tetra-O-benzyl--D-mannopyranosyloxy)-2-methylpropionate (11): Rf (1:1 diethyl ether/petroleum ether)=0.37; []D + 34.8 (c 1.32, CHCl3). 1H NMR (300 MHz, CDCl3):  = 7.37-7.16 (m, 20 H, H Ar), 4.86 (d, J1, 2 = 1.6 Hz, 1 H, H-1), 4.85 (d, Jgem = 10.72 Hz, 1 H, CH2Ph), 4.75-4.52 (m, 6 H, 3 CH2Ph), 4.51 (d, Jgem = 10.99 Hz, 1 H, CH2Ph), 3.98 (app t, J = 9.43 Hz, J = 9.43 Hz, 1 H, H-4), 3.82 (dd, J2, 3 = 2.91 Hz, J3,4 = 9.39 Hz, 1 H, H-3), 3.87-3.83 (m, 1 H, H-2), 3.78 (dd, J5, 6a = 5.40 Hz, J6a, 6b = 11.02 Hz, 1 H, H-6a), 3.73-3.70 (m, 3 H, OCH2, H-6b), 3.61 (s, 3 H, OCH3), 3.45-3.42 (m, 1 H, H-5), 2.73-2.67 (m, 1 H, CH), 1.13 (d, J = 7.10 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CDCl3):  = 174.69 (C=O), 138.52, 138.45, 138.42, 138.34 (4 C Ar), 128.35-127.26 (CH Ar), 97.88 (C1), 80.01, 74.80, 74.73, 71.99 (C2-C5), 74.85, 73.26, 72.55, 72.16 (4 CH2Ph), 69.20 (C6), 68.95 (OCH2), 51.64 (OCH3), 39.65 (CH), 13.80 (CH3) ppm. Methyl (S)-(+)-(2,3,4,6-tetra-O-benzyl--D-mannopyranosyloxy)-2-methylpropionate (11): Rf (1:1 diethyl ether/petroleum ether)=0.30; []D -43.2 (c 0.44, CHCl3). 1H NMR (300 MHz, CDCl3):  = 7.45-7.15 (m, 20 H, H Ar), 4.94 (d, Jgem = 12.56 Hz, 1 H, CH2Ph), 4.90 (d, Jgem = 10.85 Hz, 1 H, CH2Ph), 4.80 (d, Jgem = 12.51 Hz, 1 H, CH2Ph), 4.66-4.37 (m, 4 H, 2 CH2Ph), 4.52 (d, Jgem = 10.79 Hz, 1 H, CH2Ph), 4.39 (s, 1 H, H-1), 4.03-3.98 (m, 1 H, H-4), 3.89-3.82 (m, 2 H, H-2, H-3), 3.79-3.72 (m, 2 H, OCH2), 3.68 (s, 3 H, OCH3), 3.67-3.61 (m, 1 H, H-6a), 3.50-3.41 (m, 2 H, H-5, H-6b), 2.91-2.80 (m, 1 H, CH), 1.18 (d, J = 7.18 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CDCl3):  = 175.44 (C=O), 138.62, 138.37, 138.26, 137.08 (4 C Ar), 128.38-127.35 (CH Ar), 102.00 (C1), 82.13, 75.89, 74.77, 73.18 (C2-C5), 75.13, 73.63, 73.42, 71.76 (4 CH2Ph), 71.31 (C6), 69.55 (OCH2), 51.73 (OCH3), 40.27 (CH), 13.96 (CH3) ppm. Methyl (R)-(-)-(2,3,4,6-tetra-O-benzyl--D-galactopyranosyloxy)-2-methylpropionate (10): Rf (1:1 diethyl ether/petroleum ether)= 0.39; []D +30.9 (c 0.56, CHCl3). 1H NMR (300 MHz, CDCl3):  = 7.39-7.26 (m, 20 H, H Ar), 4.95 (d, Jgem = 11.47 Hz, 1 H, CH2Ph), 4.87 (d, J1, 2 = 3.54 Hz, 1 H, H-1), 4.86-4.64 (m, 4 H, 2 CH2Ph), 4.58 (d, Jgem = 11.47 Hz, 1 H, CH2Ph), 4.51-4.39 (m, 2 H, CH2Ph), 4.04 (dd, J1, 2 = 3.75 Hz, J2, 3 = 10.13 Hz, 1 H, H-2), 3.98-3.89 (m, 3 H, H-3, H-4, H-5), 3.68-3.64 (m, 2 H, H-6a, H-6b), 3.62 (s, 3 H, OCH3), 3.53 (d, J = 6.43 Hz, 2 H, OCH2), 2.89-2.78 (m, 1 H, CH), 1.19 (d, J = 7.08 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CDCl3):  = 174.91 (C=O), 138.91, 138.82, 138.76, 138.13 (4 C Ar), 128.37-127.33 (CH Ar), 98.05 (C1), 78.87, 76.65, 75.23, 70.02 (C2-C5), 74.76, 73.47, 73.16, 72.86 (4 CH2Ph), 69.63 (C6), 69.06 (OCH2), 51.59 (OCH3), 39.95 (CH), 14.13 (CH3) ppm. Methyl (R)-(-)-(2,3,4,6-tetra-O-benzyl--D-galactopyranosyloxy)-2-methylpropionate (10): Rf (1:1 diethyl ether/petroleum ether)= 0.32; []D -13.7 (c 0.42, CHCl3). 1H NMR (300 MHz, CDCl3):  = 7.37-7.25 (m, 20 H, H Ar), 4.93 (d, Jgem = 11.66 Hz, 1 H, CH2Ph), 4.88-4.69 (m, 4 H, 2 CH2Ph), 4.62 (d, Jgem = 11.67 Hz, 1 H, CH2Ph), 4.45-4.40 (m, 2 H, CH2Ph), 4.35 (d, J1, 2 = 7.73 Hz, 1 H, H-1), 4.15-4.13 (m, 1 H, H-3), 3.88 (d, J4, 5 = 2.60 Hz, 1 H, H-4), 3.80 (dd, J1, 2 = 7.74 Hz, J2,3 = 9.74 Hz, 1 H, H-2), 3.61 (s, 3 H, OCH3), 3.60-3.50 (m, 5 H, H-6a, H-6b, H-5, OCH2), 2.83-2.77 (m, 1 H, CH), 1.24 (d, J = 7.07 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CDCl3):  = 174.76 (C=O), 138.68, 138.57, 138.47, 137.89 (4 C Ar), 128.50-127.40 (CH Ar), 104.14 (C1), 82.13, 79.30, 73.44, 73.44 (C2-C5), 75.07, 74.51, 73.52, 73.07 (4 CH2Ph), 71.22 (C6), 68.74 (OCH2), 51.69 (OCH3), 40.04 (CH), 14.15 (CH3) ppm. Methyl (S)-(+)-(2,3,4,6-tetra-O-benzyl--D-galactopyranosyloxy)-2-methylpropionate (12): Rf (1:1 diethyl ether/petroleum ether)= 0.34; []D +24.2 (c 0.41, CHCl3). 1H NMR (300 MHz, CDCl3):  = 7.36-7.25 (m, 20 H, H Ar), 4.95 (d, Jgem = 11.44 Hz, 1 H, CH2Ph), 4.82 (d, J1, 2 = 3.75 Hz, 1 H, H-1), 4.80-4.63 (m, 4 H, 2 CH2Ph), 4.56 (d, Jgem = 11.44 Hz, 1 H, CH2Ph), 4.51-4.40 (m, 2 H, CH2Ph), 4.03 (dd, J1, 2 = 3.55 Hz, J2, 3 = 10.03 Hz, 1 H, H-2), 4.00-3.85 (m, 4 H, H-3, H-4, H-5, H-6a), 3.61 (s, 3 H, OCH3), 3.53 (d, J = 6.49 Hz, 2 H, OCH2), 3.40 (dd, J6a, 5 = 5.93 Hz, J6a, 6b = 9.62 Hz, 1 H, H-6b), 2.89-2.75 (m, 1 H, CH), 1.18 (d, J = 7.10 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CDCl3):  = 175.02 (C=O), 138.83, 138.73, 138.70, 138.09 (4 C Ar), 128.40-127.32 (CH Ar), 97.84 (C1), 78.82, 76.54, 75.01, 69.36 (C2-C5), 74.74, 73.35, 73.06, 73.06 (4 CH2Ph), 69.81 (C6), 68.83 (OCH2), 51.62 (OCH3), 39.79 (CH), 14.22 (CH3) ppm. Methyl (S)-(+)-(2,3,4,6-tetra-O-benzyl--D-galactopyranosyloxy)-2-methylpropionate (12): Rf (1:1 diethyl ether/petroleum ether)= 0.31; []D -20.1 (c 0.30, CHCl3). 1H NMR (300 MHz, CDCl3):  = 7.38-7.25 (m, 20 H, H Ar), 4.92 (d, Jgem = 11.64 Hz, 1 H, CH2Ph), 4.88-4.66 (m, 4 H, 2 CH2Ph), 4.61 (d, Jgem = 11.66 Hz, 1 H, CH2Ph), 4.47-4.38 (m, 2 H, CH2Ph), 4.35 (d, J1, 2 = 7.67 Hz, 1 H, H-1), 3.94-3.87 (m, 2 H, H-3, H-4), 3.81-3.70 (m, 2 H, H-2, H-5), 3.59 (s, 3 H, OCH3), 3.61-3.47 (m, 4 H, OCH2, H-6a, H-6b), 2.87-2.75 (m, 1 H, CH), 1.16 (d, J = 7.15 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CDCl3):  = 175.27 (C=O), 138.71, 138.56, 138.49, 137.88 (4 C Ar), 128.44-127.40 (CH Ar), 104.03 (C1), 82.05, 79.25, 73.46, 73.39 (C2-C5), 74.90, 74.50, 73.51, 73.10 (4 CH2Ph), 71.39 (C6), 68.77 (OCH2), 51.71 (OCH3), 40.25 (CH), 14.09 (CH3) ppm. General procedure for methyl ester hydrolysis of compounds 9-12: To a solution of pure anomer of each ester derivative 9-12 (100 mg, 0.156 mmol) in dioxan (1 mL) 10 equivalents of 1 M NaOH was added and the reaction mixture was stirred for 24 h at 40C and monitored by TLC (2:1 C6H6/EtOAc). Reaction mixtures were then neutralized with 0.5 M HCl (pH 3.5) and saturated brine was added. Mixtures were extracted with diethyl ether and organic layers dried over Na2SO4. After filtration, the organic layer was concentrated in vacuo and the residues purified by column chromatography on silica gel (9:1 CHCl3/MeOH). (R)-(-)-(2,3,4,6-Tetra-O-benzyl -  - D - mannopyranosyloxy) - 2 -methylpropionic acid (13): Pale yellow oil (91.9 mg, 94 %); Rf (9:1 CHCl3/methanol)=0.61; []D +13.1 (c 0.21, CHCl3). 1H NMR (300 MHz, CDCl3):  = 7.36-7.13 (m, 20 H, H Ar), 4.85 (d, J1, 2 = 1.77 Hz, 1 H, H-1), 4.84 (d, Jgem = 10.69 Hz, 1 H, CH2Ph), 4.74-4.51 (m, 6 H, 3 CH2Ph), 4.49 (d, Jgem = 10.80 Hz, 1 H, CH2Ph), 3.96 (app t, J = 9.29 Hz, J = 9.36 Hz, 1 H, H-4), 3.84 (dd, J2, 3 = 3.00 Hz, J3,4 = 9.21 Hz, 1 H, H-3), 3.77-3.69 (m, 5 H, OCH2, H-2, H-6a, H-6b), 3.60-3.55 (m, 1 H, H-5), 2.76-2.64 (m, 1 H, CH), 1.13 (d, J = 7.12 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CDCl3):  = 179.51 (C=O), 138.39, 138.33, 138.26, 138.26 (4 CAr), 128.31-127.46 (CHAr), 98.41 (C1), 79.93, 74.81, 74.81, 72.04 (C2-C5), 75.06, 73.33, 72.63, 72.22 (4 CH2Ph), 69.17 (C6), 69.17 (OCH2), 39.83 (CH), 13.85 (CH3) ppm. Anal. Calcd. for C38H42O8 (Mr = 626.74): C 72.82, H 6.75 %; found: C 72.75, H 6.66 %. (R)-(-)-(2,3,4,6-Tetra-O-benzyl -  - D - mannopyranosyloxy) - 2 -methylpropionic acid (13): Pale yellow oil (81.2 mg, 83 %); Rf (9:1 CHCl3/methanol)=0.50; []D -61.2 (c 0,44, CHCl3). 1H NMR (300 MHz, CDCl3):  = 7.57-7.28 (m, 20 H, H Ar), 5.06 (d, Jgem = 12.34 Hz, 1 H, CH2Ph), 5.01 (d, Jgem = 10.96 Hz, 1 H, CH2Ph), 4.94 (d, Jgem = 12.59 Hz, 1 H, CH2Ph), 4.64 (d, Jgem = 10.71 Hz, 1 H, CH2Ph), 4.77-4.56 (m, 4 H, 2 CH2Ph), 4.53 (s, 1 H, H-1), 4.29-4.24 (m, 1 H, H-4), 4.03-3.94 (m, 2 H, H-2, H-3), 3.91-3.86 (m, 2 H, OCH2), 3.76-3.71 (m, 1 H, H-6a), 3.64-3.55 (m, 2 H, H-5, H-6b), 2.98-2.91 (m, 1 H, CH), 1.37 (d, J = 7.06 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CDCl3):  = 177.43 (C=O), 138.75, 138.39, 138.39, 138.19 (4 C Ar), 128.37-127.32 (CH Ar), 101.74 (C1), 82.20, 75.99, 74.91, 73.46 (C2-C5), 75.04, 73.95, 73.86, 71.63 (4 CH2Ph), 71.22 (C6), 69.77 (OCH2), 39.88 (CH), 13.71 (CH3) ppm. Anal. Calcd. for C38H42O8 (Mr = 626.74): C 72.82, H 6.75 %; found: C 72.67, H 6.62 %. (S)-(+)-(2,3,4,6-Tetra-O-benzyl -  - D - mannopyranosyloxy) - 2 -methylpropionic acid (15): Pale yellow oil (83.1 mg, 85 %); Rf (9:1 CHCl3/methanol)=0.59; []D +16.9 (c 0.42, CHCl3). 1H NMR (300 MHz, CDCl3):  = 7.36-7.16 (m, 20 H, H Ar), 4.89 (d, J1, 2 = 1.59 Hz, 1 H, H-1), 4.88 (d, Jgem = 11.07 Hz, 1 H, CH2Ph), 4.74-4.54 (m, 6 H, 3 CH2Ph), 4.50 (d, Jgem = 10.83 Hz, 1 H, CH2Ph), 3.96 (app t, J = 9.25 Hz, J = 9.26 Hz, 1 H, H-4), 3.88 (dd, J2, 3 = 2.57 Hz, J3,4 = 9.29 Hz, 1 H, H-3), 3.87-3.84 (m, 1 H, H-2), 3.78-3.73 (m, 4 H, OCH2, H-6a, H-6b), 3.66-3.62 (m, 1 H, H-5), 3.08-3.03 (m, 1 H, CH), 1.29 (d, J = 7.06 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CDCl3):  = 179.00 (C=O), 138.45, 138.39, 138.36, 138.32 (4 CAr), 128.49-127.36 (CHAr), 98.03 (C1), 79.99, 74.83, 74.81, 72.04 (C2-C5), 75.13, 73.33, 72.67, 72.25 (4 CH2Ph), 69.18 (C6), 68.84 (OCH2), 39.59 (CH), 13.70 (CH3) ppm. Anal. Calcd. for C38H42O8 (Mr = 626.74): C 72.82, H 6.75 %; found: C 72.70, H 6.63 %. (S)-(+)-(2,3,4,6-Tetra-O-benzyl -  - D - mannopyranosyloxy) - 2 -methylpropionic acid (15): Pale yellow oil (75.3 mg, 77 %); Rf (9:1 CHCl3/methanol)=0.49; []D -41.1 (c 0.56, CHCl3). 1H NMR (300 MHz, CDCl3):  = 7.43-7.15 (m, 20 H, H Ar), 4.93 (d, Jgem = 12.55 Hz, 1 H, CH2Ph), 4.88 (d, Jgem = 10.98 Hz, 1 H, CH2Ph), 4.80 (d, Jgem = 12.47 Hz, 1 H, CH2Ph), 4.51 (d, Jgem = 10.67 Hz, 1 H, CH2Ph), 4.40 (s, 1 H, H-1), 4.64-4.38 (m, 4 H, 2 CH2Ph), 4.02-3.97 (m, 1 H, H-4), 3.89-3.82 (m, 2 H, H-2, H-3), 3.81-3.63 (m, 3 H, H-6a, OCH2), 3.50-3.43 (m, 2 H, H-5, H-6b), 2.91-2.80 (m, 1 H, CH), 1.20 (d, J = 7.09 Hz, 3 H, CH3) ppm.13C NMR (300 MHz, CDCl3):  = 179.41 (C=O), 138.51, 138.19, 138.19, 138.04 (4 C Ar), 128.40-127.39 (CH Ar), 101.95 (C1), 82.11, 75.77, 74.71, 73.29 (C2-C5), 75.12, 73.75, 73.42, 71.63 (4 CH2Ph), 71.39 (C6), 69.50 (OCH2), 40.28 (CH), 13.75 (CH3) ppm. Anal. Calcd. for C38H42O8 (Mr = 626.74): C 72.82, H 6.75 %; found: C 72.64, H 6.59 %. (R)-(-)-(2,3,4,6-Tetra-O-benzyl -  - D - galactopyranosyloxy) - 2 -methylpropionic acid (14): Pale yellow oil (80.2 mg, 82 %); Rf (9:1 CHCl3/methanol)=0.66; []D +15.6 (c 0.42, CHCl3). 1H NMR (300 MHz, CDCl3):  = 7.35-7.25 (m, 20 H, H Ar), 4.92 (d, Jgem = 11.47 Hz, 1 H, CH2Ph), 4.81 (d, J1, 2 = 3.86 Hz, 1 H, H-1), 4.78-4.64 (m, 4 H, 2 CH2Ph), 4.55 (d, Jgem = 11.48 Hz, 1 H, CH2Ph), 4.49-4.37 (m, 2 H, CH2Ph), 4.03 (dd, J1, 2 = 3.70 Hz, J2, 3 = 9.91 Hz, 1 H, H-2), 3.94-3.87 (m, 3 H, H-3, H-4, H-5), 3.69 (dd, J6a, 5 = 5.79 Hz, J6a, 6b = 9.88 Hz, 1 H, H-6a), 3.63-3.50 (m, 3 H, H-6b, OCH2), 2.85-2.74 (m, 1 H, CH), 1.17 (d, J = 7.12 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CDCl3):  = 177.89 (C=O), 138.65, 138.51, 138.37, 137.82 (4 CAr), 128.45-127.38 (CHAr), 98.46 (C1), 78.86, 76.11, 74.84, 69.76 (C2-C5), 74.71, 73.50, 73.28, 73.10 (4 CH2Ph), 70.02 (C6), 69.07 (OCH2), 39.45 (CH), 13.59 (CH3) ppm. Anal. Calcd. for C38H42O8 (Mr = 626.74): C 72.82, H 6.75 %; found: C 72.60, H 6.65 %. (R)-(-)-(2,3,4,6-Tetra-O-benzyl -  - D - galactopyranosyloxy) - 2 -methylpropionic acid (14): Pale yellow oil (77.2 mg, 79 %); Rf (9:1 CHCl3/methanol)=0.53; []D -15.5 (c 0.46, CHCl3). 1H NMR (300 MHz, CDCl3):  = 7.36-7.22 (m, 20 H, H Ar), 4.89 (d, Jgem = 11.51 Hz, 1 H, CH2Ph), 4.84-4.62 (m, 4 H, 2 CH2Ph), 4.57 (d, Jgem = 11.70 Hz, 1 H, CH2Ph), 4.49-4.39 (m, 2 H, CH2Ph), 4.36 (d, J1, 2 = 7.69 Hz, 1 H, H-1), 4.14-4.09 (m, 1 H, H-3), 3.78 (dd, J1, 2 = 7.90 Hz, J2, 3 = 9.76 Hz, 1 H, H-2), 3.74 (d, J4, 5 = 2.67 Hz, 1 H, H-4), 3.68-3.45 (m, 5 H, OCH2, H-6a, H-6b, H-5), 2.84-2.72 (m, 1 H, CH), 1.24 (d, J = 7.24 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CDCl3):  = 178.64 (C=O), 138.60, 138.43, 138.43, 137.62 (4 C Ar), 128.43-127.38 (CH Ar), 104.06 (C1), 82.11, 79.34, 73.42, 73.15 (C2-C5), 75.19, 74.38, 73.50, 72.97 (4 CH2Ph), 71.03 (C6), 68.98 (OCH2), 39.83 (CH), 13.80 (CH3) ppm. Anal. Calcd. for C38H42O8 (Mr = 626.74): C 72.82, H 6.75 %; found: C 72.64, H 6.60 %. 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>$>,>.>0>4><>>>@>D>F>R>V>`>d>h>j>l>n>r>|>~>>>>>>>>>>>๪|rhcYaJmHsHhcY0J.6aJmHsHhyaJmHsHhcYaJmHsHh5fhcYaJmHsHh5fhcYaJmHsHUh5fhcY0J.6aJmHsHhcY0J.aJmHsHh5fhcY0J.aJh5fhcY0J.aJmHsHh5fhcY0J.H*aJmHsH,60, 138.52, 138.23, 137.87 (4 C Ar), 128.48-127.34 (CH Ar), 97.96 (C1), 78.85, 76.25, 74.83, 69.60 (C2-C5), 74.73, 73.52, 73.37, 72.96 (4 CH2Ph), 69.63 (C6), 68.87 (OCH2), 39.47 (CH), 13.72 (CH3) ppm. Anal. Calcd. for C38H42O8 (Mr = 626.74): C 72.82, H 6.75 %; found: C 72.59, H 6.67 %. (S)-(+)-(2,3,4,6-Tetra-O-benzyl -  - D - galactopyranosyloxy) - 2 -methylpropionic acid (16): Pale yellow oil (80.2 mg, 82 %); Rf (9:1 CHCl3/methanol)=0.59; []D -4.5 (c 0.76, CHCl3). 1H NMR (300 MHz, CDCl3):  = 7.33-7.21 (m, 20 H, H Ar), 4.89 (d, Jgem = 11.71 Hz, 1 H, CH2Ph), 4.86-4.62 (m, 4 H, 2 CH2Ph), 4.57 (d, Jgem = 11.70 Hz, 1 H, CH2Ph), 4.49-4.42 (m, 2 H, CH2Ph), 4.37 (d, J1, 2 = 7.78 Hz, 1 H, H-1), 3.95-3.90 (m, 1 H, H-3), 3.80-3.70 (m, 3 H, H-2, H-4, H-5), 3.60-3.46 (m, 4 H, OCH2, H-6a, H-6b), 2.85-2.74 (m, 1 H, CH), 1.17 (d, J = 7.12 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CDCl3):  = 178.51 (C=O), 138.55, 138.42, 138.39, 137.68 (4 C Ar), 128.46-127.41 (CH Ar), 104.04 (C1), 82.03, 79.23, 73.45, 73.30 (C2-C5), 75.11, 74.45, 73.52, 73.04 (4 CH2Ph), 71.37 (C6), 68.86 (OCH2), 40.08 (CH), 13.78 (CH3) ppm. Anal. Calcd. for C38H42O8 (Mr = 626.74): C 72.82, H 6.75 %; found: C 72.65, H 6.62 %. General procedure for the synthesis of AMA glycoconjugates (17-20): To a solution of pure anomer of each carboxylic acid derivative 13-16 (100 mg, 0.16 mmol) in dry DCM at 0 C EDCxHCl (25.4 mg, 0.208 mmol, 1.3 equiv) previously mixed with Et3N (28.8 L) was added. The mixtures were then stirred for 0.5 h at the same temperature. HOBt (21.6 mg, 0.16 mmol, 1 equiv) was added next and the mixtures were left stirring for additional 2 h. During that time the temperature was allowed to gradually warm up to room temperature. AMAxHCl (150.1 mg, 0.8 mmol) previously mixed with Et3N (110.9 L) was added next and the reactions were left stirring overnight. After the neutralization with 0.5 M HCl (pH 3.5) the mixtures were extracted with DCM, combined organic layers washed with saturated NaHCO3 and dried over Na2SO4. After filtration, the organic layers were concentrated in vacuo and the residues purified by column chromatography on silica gel (2:1 C6H6/EtOAc). (R)-(-)-N-(Adamant-1-yl) - 3 - (2,3,4,6-tetra - O - benzyl -  - D -mannopyranosyloxy) - 2 - methylpropanamide (17): Pale yellow oil (69.3 mg, 57 %); Rf (2:1 C6H6/EtOAc)=0.44; []D -7.8 (c 1.03, CHCl3). 1H NMR (300 MHz, CDCl3):  = 7.36-7.16 (m, 20 H, H Ar), 5.62 (s, 1 H, N H), 4.90 (d, Jgem = 10.87 Hz, 1 H, CH2Ph), 4.88 (s, 1 H, H-1), 4.75-4.54 (m, 6 H, 3 CH2Ph), 4.51 (d, Jgem = 11.04 Hz, 1 H, CH2Ph), 3.91-3.64 (m, 7 H, H-2, H-3, H-4, H-6a, H-6b, OCH2), 3.54-3.49 (m, 1 H, H-5), 2.53-2.42 (m, 1 H, CH), 1.99 (s, 3 H, 3 CH-AMA), 1.88 (s, 6 H, 3 CH2 AMA), 1.60 (s, 6 H, 3 CH2 AMA), 0.97 (d, J = 6.94 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CDCl3):  = 173.64 (C=O), 138.54, 138.38, 138.17, 138.05 (4 C Ar), 128.47-127.31 (CH Ar), 99.54 (C1), 80.23, 75.08, 74.57, 71.93 (C2-C5), 74.84, 73.58, 72.59, 72.20 (4 CH2Ph), 71.99 (C6), 69.90 (OCH2), 51.62 (C N), 42.09 (CH), 41.54 (CH2 AMA), 36.30 (CH2 AMA), 29.37 (CH-AMA), 14.16 (CH3) ppm. Anal. Calcd. for C48H57NO7 (Mr = 759.97): C 75.86, H 7.56, N 1.84 %; found: C 75.74, H 7.52, N 1.94 %. (R)-(-)-N-(Adamant-1-yl) - 3 - (2,3,4,6-tetra - O - benzyl -  - D -mannopyranosyloxy) - 2 - methylpropanamide (17): Pale yellow oil (66.9 mg, 55 %); Rf (2:1 C6H6/EtOAc)=0.37; []D -59.4 (c 0.32, CHCl3). 1H NMR (300 MHz, CDCl3):  = 7.46-7.17 (m, 20 H, H Ar), 5.80 (s, 1 H, N H), 4.95 (d, Jgem = 12.46 Hz, 1 H, CH2Ph), 4.90 (d, Jgem = 11.01 Hz, 1 H, CH2Ph), 4.83 (d, Jgem = 12.34 Hz, 1 H, CH2Ph), 4.55 (d, Jgem = 11.78 Hz, 1 H, CH2Ph), 4.65-4.47 (m, 4 H, 2 CH2Ph), 4.39 (s, 1 H, H-1), 4.06-4.00 (m, 1 H, H-4), 3.93-3.87 (m, 2 H, H-2, H-3), 3.85-3.71 (m, 2 H, OCH2), 3.53-3.42 (m, 3 H, H-5, H-6a, H-6b), 2.55-2.44 (m, 1 H, CH), 1.97 (s, 3 H, 3 CH-AMA), 1.93 (s, 6 H, 3 CH2 AMA), 1.59 (s, 6 H, 3 CH2 AMA), 1.16 (d, J = 7.08 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CDCl3):  = 173.02 (C=O), 138.64, 138.29, 138.25, 138.08 (4 C Ar), 128.44-127.34 (CH Ar), 101.34 (C1), 82.22, 75.86, 74.82, 74.02 (C2-C5), 75.13, 73.99, 73.47, 71.81 (4 CH2Ph), 71.60 (C6), 69.62 (OCH2), 51.62 (C N), 41.57 (CH), 41.43 (CH2 AMA), 36.33 (CH2 AMA), 29.39 (CH-AMA), 14.25 (CH3) ppm. Anal. Calcd. for C48H57NO7 (Mr = 759.97): C 75.86, H 7.56, N 1.84 %; found: C 75.76, H 7.50, N 1.89 %. (S)-(+)-N-(Adamant-1-yl) - 3 - (2,3,4,6-tetra - O - benzyl -  - D -mannopyranosyloxy) - 2 - methylpropanamide (19): Pale yellow oil (69.3 mg, 57 %); Rf (2:1 C6H6/EtOAc)=0.46; []D +11.9 (c 0.42, CHCl3). 1H NMR (300 MHz, CDCl3):  = 7.38-7.14 (m, 20 H, H Ar), 5.32 (s, 1 H, N H), 4.90-4.50 (m, 8 H, 4 CH2Ph), 4.87 (s, 1 H, H-1), 4.01 (app t, J = 9.32 Hz, J = 9.40 Hz, 1 H, H-4), 3.84 (dd, J2, 3 = 2.69 Hz, J3, 4 = 9.36 Hz, 1 H, H-3), 3.80-3.70 (m, 5 H, OCH2, H-2, H-6a, H-6b), 3.33-3.30 (m, 1 H, H-5), 2.36-2.31 (m, 1 H, CH), 1.95 (s, 3 H, 3 CH-AMA), 1.90 (s, 6 H, 3 CH2 AMA), 1.58 (s, 6 H, 3 CH2 AMA), 1.05 (d, J = 6.88 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CDCl3):  = 173.10 (C=O), 138.71, 138.49, 138.39, 138.28 (4 C Ar), 128.33-127.32 (CH Ar), 97.84 (C1), 80.18, 74.85, 74.59, 71.91 (C2-C5), 74.82, 73.28, 72.52, 72.22 (4 CH2Ph), 70.01 (C6), 69.07 (OCH2), 51.62 (C N), 41.79 (CH), 41.67 (CH2 AMA), 36.32 (CH2 AMA), 29.38 (CH-AMA), 14.12 (CH3) ppm. Anal. Calcd. for C48H57NO7 (Mr = 759.97): C 75.86, H 7.56, N 1.84 %; found: C 75.75, H 7.59, N 1.89 %. (S)-(+)-N-(Adamant-1-yl) - 3 - (2,3,4,6-tetra - O - benzyl -  - D -mannopyranosyloxy) - 2 - methylpropanamide (19): Pale yellow oil (68.1 mg, 56 %); Rf (2:1 C6H6/EtOAc)=0.31; []D -23.0 (c 0.43, CHCl3). 1H NMR (300 MHz, CDCl3):  = 7.46-7.17 (m, 20 H, H Ar), 5.80 (s, 1 H, N H), 4.95 (d, Jgem = 12.47 Hz, 1 H, CH2Ph), 4.90 (d, Jgem = 11.00 Hz, 1 H, CH2Ph), 4.83 (d, Jgem = 12.34 Hz, 1 H, CH2Ph), 4.55 (d, Jgem = 11.78 Hz, 1 H, CH2Ph), 4.65-4.47 (m, 4 H, 2 CH2Ph), 4.39 (s, 1 H, H-1), 4.06-4.00 (m, 1 H, H-4), 3.93-3.87 (m, 2 H, H-2, H-3), 3.83-3.70 (m, 2 H, OCH2), 3.53-3.42 (m, 3 H, H-5, H-6a, H-6b), 2.55-2.44 (m, 1 H, CH), 1.97 (s, 3 H, 3 CH-AMA), 1.92 (s, 6 H, 3 CH2 AMA), 1.59 (s, 6 H, 3 CH2 AMA), 1.16 (d, J = 7.08 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CDCl3):  = 173.02 (C=O), 138.64, 138.30, 138.25, 138.08 (4 C Ar), 128.44-127.34 (CH Ar), 101.34 (C1), 82.22, 75.86, 74.82, 74.02 (C2-C5), 75.13, 73.99, 73.47, 71.80 (4 CH2Ph), 71.60 (C6), 69.62 (OCH2), 51.62 (C N), 41.57 (CH), 41.43 (CH2 AMA), 36.32 (CH2 AMA), 29.38 (CH-AMA), 14.25 (CH3) ppm. Anal. Calcd. for C48H57NO7 (Mr = 759.97): C 75.86, H 7.56, N 1.84 %; found: C 75.76, H 7.55, N 1.94 %. (R)-(-)-N-(Adamant-1-yl) - 3 - (2,3,4,6-tetra - O - benzyl -  - D -galactopyranosyloxy) - 2 - methylpropanamide (18): Pale yellow oil (68.1 mg, 56 %); Rf (2:1 C6H6/EtOAc)=0.64; []D +10.6 (c 0.72, CHCl3). 1H NMR (300 MHz, CDCl3):  = 7.39-7.25 (m, 20 H, H Ar), 5.96 (s, 1 H, N H), 4.96 (d, Jgem = 11.12 Hz, 1 H, CH2Ph), 4.84 (d, J1, 2 = 3.66 Hz, 1 H, H-1), 4.81-4.66 (m, 4 H, 2 CH2Ph), 4.58 (d, Jgem = 11.49 Hz, 1 H, CH2Ph), 4.51-4.37 (m, 2 H, CH2Ph), 4.04 (dd, J1, 2 = 3.63 Hz, J2, 3 = 9.86 Hz, 1 H, H-2), 3.97 (app t, J = 6.37 Hz, J = 6.53 Hz, 1 H, H-5), 3.93-3.87 (m, 2 H, H-3, H-4), 3.68-3.44 (m, 4 H, H-6a, H-6b, OCH2), 2.54-2.43 (m, 1 H, CH), 1.96 (s, 3 H, 3 CH-AMA), 1.89 (s, 6 H, 3 CH2 AMA), 1.59 (s, 6 H, 3 CH2 AMA), 1.06 (d, J = 7.07 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CDCl3):  = 173.47 (C=O), 138.70, 138.56, 138.54, 137.76 (4 C Ar), 128.35-127.38 (CH Ar), 98.78 (C1), 79.02, 76.43, 75.19, 69.70 (C2-C5), 74.71, 73.60, 73.22, 73.18 (4 CH2Ph), 71.46 (C6), 69.44 (OCH2), 51.48 (C N), 41.73 (CH), 41.49 (CH2 AMA), 36.34 (CH2 AMA), 29.38 (CH-AMA), 14.33 (CH3) ppm. Anal. Calcd. for C48H57NO7 (Mr = 759.97): C 75.86, H 7.56, N 1.84 %; found: C 75.69, H 7.60, N 1.89 %. (R)-(-)-N-(Adamant-1-yl) - 3 - (2,3,4,6-tetra - O - benzyl -  - D -galactopyranosyloxy) - 2 - methylpropanamide (18): Pale yellow oil (67.0 mg, 55 %); Rf (2:1 C6H6/EtOAc)=0.53; []D -7.3 (c 0.66, CHCl3). 1H NMR (300 MHz, CDCl3):  = 7.36-7.25 (m, 20 H, H Ar), 5.76 (br s, 1 H, N H), 4.94 (d, Jgem = 11.57 Hz, 1 H, CH2Ph), 4.90-4.73 (m, 4 H, 2 CH2Ph), 4.58 (d, Jgem = 11.58 Hz, 1 H, CH2Ph), 4.48-4.39 (m, 2 H, CH2Ph), 4.35 (d, J1, 2 = 7.63 Hz, 1 H, H-1), 4.00-3.94 (m,1 H, H-3), 3.90 (d, J4, 5 = 2.79 Hz, 1 H, H-4), 3.78 (dd, J1, 2 = 7.69 Hz, J2, 3 = 9.68 Hz, 1 H, H-2), 3.60-3.48 (m, 5 H, H-5, H-6a, H-6b, OCH2), 2.50-2.39 (m, 1 H, CH), 1.96 (s, 3 H, 3 CH-AMA), 1.92 (s, 6 H, 3 CH2 AMA), 1.60 (s, 6 H, 3 CH2 AMA), 1.12 (d, J = 7.07 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CDCl3):  = 173.08 (C=O), 138.70, 138.63, 138.37, 137.77 (4 C Ar), 128.44-127.46 (CH Ar), 103.44 (C1), 82.17, 79.42, 73.56, 73.39 (C2-C5), 75.18, 74.59, 73.58, 72.95 (4 CH2Ph), 71.64 (C6), 68.59 (OCH2), 51.59 (C N), 41.45 (CH2 AMA), 41.42 (CH), 36.38 (CH2 AMA), 29.39 (CH-AMA), 14.06 (CH3) ppm. Anal. Calcd. for C48H57NO7 (Mr = 759.97): C 75.86, H 7.56, N 1.84 %; found: C 75.72, H 7.57, N 1.92 %. (S)-(+)-N-(Adamant-1-yl) - 3 - (2,3,4,6-tetra - O - benzyl -  - D -galactopyranosyloxy) - 2 - methylpropanamide (20): Pale yellow oil (80.2 mg, 66 %); Rf (2:1 C6H6/EtOAc)=0.53; []D +31.8 (c 0.40, CHCl3). 1H NMR (300 MHz, CDCl3):  = 7.37-7.25 (m, 20 H, H Ar), 6.09 (s, 1 H, N H), 4.94 (d, Jgem = 11.36 Hz, 1 H, CH2Ph), 4.73 (d, J1, 2 = 3.43 Hz, 1 H, H-1), 4.81-4.65 (m, 4 H, 2 CH2Ph), 4.58 (d, Jgem = 11.37 Hz, 1 H, CH2Ph), 4.53-4.39 (m, 2 H, CH2Ph), 4.05 (dd, J1, 2 = 3.48 Hz, J2, 3 = 10.05 Hz, 1 H, H-2), 4.00-3.89 (m, 3 H, H-3, H-4, H-5), 3.74-3.37 (m, 4 H, H-6a, H-6b, OCH2), 2.45-2.38 (m, 1 H, CH), 1.96 (s, 3 H, 3 CH-AMA), 1.89 (s, 6 H, 3 CH2 AMA), 1.59 (s, 6 H, 3 CH2 AMA), 1.05 (d, J = 6.98 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CDCl3):  = 173.57 (C=O), 138.61, 138.61, 138.29, 138.03 (4 C Ar), 128.39-127.25 (CH Ar), 97.85 (C1), 79.28, 76.40, 74.88, 69.38 (C2-C5), 74.85, 73.88, 73.32, 72.92 (4 CH2Ph), 70.60 (C6), 68.54 (OCH2), 51.55 (C N), 41.51 (CH2 AMA), 41.07 (CH), 36.36 (CH2 AMA), 29.39 (CH-AMA), 13.67 (CH3) ppm. Anal. Calcd. for C48H57NO7 (Mr = 759.97): C 75.86, H 7.56, N 1.84 %; found: C 75.68, H 7.62, N 1.93 %. (S)-(+)-N-(Adamant-1-yl) - 3 - (2,3,4,6-tetra - O - benzyl -  - D -galactopyranosyloxy) - 2 - methylpropanamide (20): Pale yellow oil (73.0 mg, 60 %); Rf (2:1 C6H6/EtOAc)=0.45; []D +16.3 (c 0.82, CHCl3). 1H NMR (300 MHz, CDCl3):  = 7.37-7.25 (m, 20 H, H Ar), 5.90 (br s, 1 H, N H), 4.94 (d, Jgem = 11.54 Hz, 1 H, CH2Ph), 4.90-4.69 (m, 4 H, 2 CH2Ph), 4.57 (d, Jgem = 11.55 Hz, 1 H, CH2Ph), 4.44 (br s, 2 H, CH2Ph), 4.37 (d, J1, 2 = 6.62 Hz, 1 H, H-1), 3.88-3.69 (m, 4 H, H-2, H-3, H-4, H-5), 3.61-3.49 (m, 4 H, OCH2, H-6a, H-6b), 2.58-2.48 (m, 1 H, CH), 1.98 (s, 3 H, 3 CH-AMA), 1.91 (s, 6 H, 3 CH2 AMA), 1.57 (s, 6 H, 3 CH2 AMA), 1.05 (d, J = 6.90 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CDCl3):  = 173.77 (C=O), 138.62, 138.58, 138.40, 137.68 (4 C Ar), 128.52-127.46 (CH Ar), 104.76 (C1), 81.97, 79.43, 73.73, 73.36 (C2-C5), 75.14, 74.65, 73.58, 73.10 (4 CH2Ph), 73.00 (C6), 68.82 (OCH2), 51.60 (C N), 42.19 (CH), 41.47 (CH2 AMA), 36.37 (CH2 AMA), 29.36 (CH-AMA), 13.89 (CH3) ppm. Anal. Calcd. for C48H57NO7 (Mr = 759.97): C 75.86, H 7.56, N 1.84 %; found: C 75.70, H 7.59, N 1.90 %. General procedure for debenzylation of AMA conjugates 17-20. To a solution of pure anomer of each AMA conjugate 17-20 (100 mg, 0.132 mmol) in DCM (5 mL) 50 mg of 10 % Pd/C and 20 mL of CH3OH was added. The mixtures were subjected to hydrogen atmosphere under 4 bars at room temperature and stirred for 24 h. Then they were filtrated over a celite bed and the filtrates concentrated in vacuo. The residues were purified by column chromatography on silicagel (5:1 acetonitrile/H2O) and the compounds (21-24) were obtained. (R)-(-)-N-(Adamant-1-yl) - 3 -  - D -mannopyranosyloxy - 2 - methylpropanamide (21): Pale yellow crude foam (49.4 mg, 94 %); Rf (5:1 acetonitrile/H2O)=0.58; []D +17.2 (c 0.64, CH3OH). 1H NMR (300 MHz, CD3OD):  = 7.30 (s, 1 H, N H), 4.71 (d, J1, 2 = 1.47 Hz, 1 H, H-1), 3.85-3.80 (m, 1 H, H-3), 3.83 (dd, J6b, 5 = 1.84 Hz, J6a, 6b = 11.68 Hz, H-6b), 3.76 (dd, J1, 2 = 1.62 Hz, J2, 3 = 3.02 Hz, 1 H, H-2), 3.72-3.45 (m, 6 H, H-3, H-4, H-5, H-6a, OCH2), 2.65-2.53 (m, 1 H, CH), 2.02 (br s, 9 H, 3 CH-AMA, 3 CH2 AMA), 1.71 (s, 6 H, 3 CH2 AMA), 1.01 (d, J = 6.94 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CD3OD):  = 176.73 (C=O), 102.28 (C1), 74.72, 72.67, 72.13, 68.62 (C2-C5), 71.55 (C6), 62.94 (OCH2), 52.86 (C N), 42.82 (CH), 42.44 (CH2 AMA), 37.56 (CH2 AMA), 30.97 (CH-AMA), 14.64 (CH3) ppm. Anal. Calcd. for C20H33NO7 (Mr = 399.48): C 60.13, H 8.33, N 3.51 %; found: C 59.94, H 8.23, N 3.65 %. (R)-(-)-N-(Adamant-1-yl) - 3 -  - D -mannopyranosyloxy - 2 - methylpropanamide (21): Pale yellow crude foam (46.3 mg, 88 %); Rf (5:1 acetonitrile/H2O)=0.53; []D -45.7 (c 0.70, CH3OH). 1H NMR (300 MHz, CD3OD):  = 7.26 (s, 1 H, N H), 4.20 (d, J1, 2 = 0.63 Hz, 1 H, H-1), 3.96-3.93 (m, 1 H, H-4), 3.87 (dd, J6a, 5 = 2.34 Hz, J6a, 6b = 11.78 Hz, 1 H, H-6a), 3.84 (d, J2, 3 = 3.06 Hz, 1 H, H-2), 3.71 (dd, J6b, 5 = 6.02 Hz, J6a, 6b = 11.79 Hz, 1 H, H-6b), 3.56-3.51 (m, 2 H, OCH2), 3.45 (dd, J2, 3 = 3.22 Hz, J3, 4 = 9.39 Hz, 1 H, H-3), 3.22-3.19 (m, 1 H, H-5), 2.63-2.57 (m, 1 H, CH), 2.04 (s, 3 H, 3 CH-AMA), 2.03 (s, 6 H, 3 CH2 AMA), 1.72 (s, 6 H, 3 CH2 AMA), 1.07 (d, J = 6.96 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CD3OD):  = 176.64 (C=O), 101.29 (C1), 78.35, 75.29, 72.48, 68.65 (C2-C5), 72.29 (C6), 62.92 (OCH2), 52.93 (C N), 42.43 (CH2 AMA), 42.36 (CH), 37.57 (CH2 AMA), 30.98 (CH-AMA), 14.79 (CH3) ppm. Anal. Calcd. for C20H33NO7 (Mr = 399.48): C 60.13, H 8.33, N 3.51 %; found: C 60.02, H 8.28, N 3.63 %. (S)-(+)-N-(Adamant-1-yl) - 3 -  - D -mannopyranosyloxy - 2 - methylpropanamide (23): Pale yellow crude foam (47.3 mg, 90 %); Rf (5:1 acetonitrile/H2O)=0.61; []D +46.6 (c 0.88, CH3OH). 1H NMR (300 MHz, CD3OD):  = 7.27 (s, 1 H, N H), 4.74 (d, J1, 2 = 1.46 Hz, 1 H, H-1), 3.83 (dd, J6b, 5 = 2.38 Hz, J6a, 6b = 11.74 Hz, 1 H, H-6b), 3.80 (app t, J = 9.26 Hz, J = 9.27 Hz, 1 H, H-4), 3.77 (dd, J1, 2 = 1.67 Hz, J2, 3 = 3.25 Hz, 1 H, H-2), 3.67 (dd, J2, 3 = 3.30 Hz, J3, 4 = 9.40 Hz, 1 H, H-3), 3.72-3.61 (m, 3 H, OCH2, H-6a), 3.55-3.52 (m, 1 H, H-5), 2.62-2.57 (m, 1 H, CH), 2.03 (br s, 9 H, 3 CH-AMA, 3 CH2 AMA), 1.72 (s, 6 H, 3 CH2 AMA), 1.04 (d, J = 6.93 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CD3OD):  = 176.53 (C=O), 101.38 (C1), 74.44, 72.77, 72.24, 68.52 (C2-C5), 70.71 (C6), 62.87 (OCH2), 52.90 (C N), 42.50 (CH2 AMA), 42.41 (CH), 37.57 (CH2 AMA), 30.97 (CH-AMA), 14.69 (CH3) ppm. Anal. Calcd. for C20H33NO7 (Mr = 399.48): C 60.13, H 8.33, N 3.51 %; found: C 60.00, H 8.21, N 3.69 %. (S)-(+)-N-(Adamant-1-yl) - 3 -  - D -mannopyranosyloxy - 2 - methylpropanamide (23): Pale yellow crude foam (45.7 mg, 87 %); Rf (5:1 acetonitrile/H2O)=0.59; []D -9.0 (c 0.512, CH3OH). 1H NMR (300 MHz, CD3OD):  = 7.25 (s, 1 H, N H), 4.48 (d, J1, 2 = 0.74 Hz, 1 H, H-1), 3.88 (dd, J6a, 5 = 2.36 Hz, J6a, 6b = 11.75 Hz, 1 H, H-6a), 3.83 (d, J2, 3 = 3.17 Hz, 1 H, H-2), 3.80-3.77 (m, 1 H, H-4), 3.71 (dd, J6b, 5 = 5.91 Hz, J6a, 6b = 11.76 Hz, 1 H, H-6b), 3.64-3.53 (m, 2 H, OCH2), 3.43 (dd, J2, 3 = 3.22 Hz, J3, 4 = 9.39 Hz, 1 H, H-3), 3.22-3.19 (m, 1 H, H-5), 2.63-2.57 (m, 1 H, CH), 2.04 (s, 3 H, 3 CH-AMA), 2.03 (s, 6 H, 3 CH2 AMA), 1.71 (s, 6 H, 3 CH2 AMA), 1.02 (d, J = 7.00 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CD3OD):  = 176.89 (C=O), 102.29 (C1), 78.34, 75.32, 72.53, 68.62 (C2-C5), 73.14 (C6), 62.88 (OCH2), 52.92 (C N), 42.96 (CH), 42.42 (CH2 AMA), 37.58 (CH2 AMA), 30.98 (CH-AMA), 14.45 (CH3) ppm. Anal. Calcd. for C20H33NO7 (Mr = 399.48): C 60.13, H 8.33, N 3.51 %; found: C 60.05, H 8.20, N 3.65 %. (R)-(-)-N-(Adamant-1-yl) - 3 -  - D -galactopyranosyloxy - 2 - methylpropanamide (22): Pale yellow crude foam (50.1 mg, 95 %); Rf (5:1 acetonitrile/H2O)=0.56; []D +54.2 (c 0.50, CH3OH). 1H NMR (300 MHz, CD3OD):  = 4.87 (s, 1 H, N H), 4.81 (d, J1, 2 = 3.24 Hz, 1 H, H-1), 3.87-3.65 (m, 6 H, H-2, H-3, H-4, H-5, H-6a, H-6b), 3.61 (d, J = 6.79 Hz, 2 H, OCH2), 2.71-2.60 (m, 1 H, CH), 2.04 (br s, 9 H, 3 CH-AMA, 3 CH2 AMA), 1.70 (s, 6 H, 3 CH2 AMA), 1.05 (d, J = 6.98 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CD3OD):  = 176.76 (C=O), 101.21 (C1), 72.58, 71.74, 71.15, 70.38 (C2-C5), 72.20 (C6), 62.90 (OCH2), 52.88 (C N), 42.78 (CH), 42.36 (CH2 AMA), 37.54 (CH2 AMA), 30.95 (CH-AMA), 14.87 (CH3) ppm. Anal. Calcd. for C20H33NO7 (Mr = 399.47): C 60.13, H 8.33, N 3.51 %; found: C 60.01, H 8.25, N 3.32 %. (R)-(-)-N-(Adamant-1-yl) - 3 -  - D -galactopyranosyloxy - 2 - methylpropanamide (22): Pale yellow crude foam (49.6 mg, 94 %); Rf (5:1 acetonitrile/H2O)=0.54; []D -18.1 (c 0.62, CH3OH). 1H NMR (300 MHz, CD3OD):  = 7.23 (br s, 1 H, N H), 4.23 (d, J1, 2 = 7.06 Hz, 1 H, H-1), 3.98-3.92 (m, 1 H, H-3), 3.83 (d, J4, 5 = 2.77 Hz, 1 H, H-4), 3.80-3.68 (m, 2 H, H-2, H-5), 3.52-3.45 (m, 4 H, H-6a, H-6b, OCH2), 2.67-2.55 (m, 1 H, CH), 2.03 (s, 9 H, 3 CH-AMA, 3 CH2 AMA), 1.71 (s, 6 H, 3 CH2 AMA), 1.07 (d, J = 6.96 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CD3OD):  = 176.72 (C=O), 104.84 (C1), 76.72, 75.02, 72.40, 70.41 (C2-C5), 72.57 (C6), 62.57 (OCH2), 52.90 (C N), 42.54 (CH), 42.37 (CH2 AMA), 37.55 (CH2 AMA), 30.94 (CH-AMA), 14.73 (CH3) ppm. Anal. Calcd. for C20H33NO7 (Mr = 399.48): C 60.13, H 8.33, N 3.51 %; found: C 60.07, H 8.22, N 3.29 %. (S)-(+)-N-(Adamant-1-yl) - 3 -  - D -galactopyranosyloxy - 2 - methylpropanamide (24): Pale yellow crude foam (49.0 mg, 93 %); Rf (5:1 acetonitrile/H2O)=0.56; []D +131.8 (c 0.44, CH3OH). 1H NMR (300 MHz, CD3OD):  = 7.32 (br s, 1 H, N H), 4.77 (d, J1, 2 = 3.25 Hz, 1 H, H-1), 3.85-3.83 (m, 1 H, H-2), 3.80-3.64 (m, 6 H, H-3, H-4, H-5, H-6a, OCH2), 3.25 (dd, J6a, 5 = 4.64 Hz, J6a, 6b = 9.19 Hz, 1 H, H-6b), 2.69-2.56 (m, 1 H, CH), 2.08 (br s, 9 H, 3 CH-AMA, 3 CH2 AMA), 1.70 (s, 6 H, 3 CH2 AMA), 1.02 (d, J = 6.95 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CD3OD):  = 176.82 (C=O), 100.08 (C1), 72.14, 71.67, 71.07, 70.17 (C2-C5), 71.04 (C6), 62.74 (OCH2), 52.87 (C N), 42.50 (CH2 AMA), 42.40 (CH), 37.54 (CH2 AMA), 30.95 (CH-AMA), 14.33 (CH3) ppm. Anal. Calcd. for C20H33NO7 (Mr = 399.48): C 60.13, H 8.33, N 3.51 %; found: C 60.02, H 8.30, N 3.35 %. (S)-(+)-N-(Adamant-1-yl) - 3 -  - D -galactopyranosyloxy - 2 - methylpropanamide (24): Pale yellow crude foam (48.0 mg, 91 %); Rf (5:1 acetonitrile/H2O)=0.55; []D +24.4 (c 0.57, CH3OH). 1H NMR (300 MHz, CD3OD):  = 4.84 (s, 1 H, N H), 4.21 (d, J1, 2 = 7.48 Hz, 1 H, H-1), 3.82-3.68 (m, 5 H, H-2, H-3, H-4, H-5, H-6a), 3.52-3.45 (m, 3 H, H-6b, OCH2), 2.66-2.61 (m, 1 H, CH), 2.04 (s, 9 H, 3 CH-AMA, 3 CH2 AMA), 1.71 (s, 6 H, 3 CH2 AMA), 1.03 (d, J = 6.99 Hz, 3 H, CH3) ppm. 13C NMR (300 MHz, CD3OD):  = 176.81 (C=O), 105.59 (C1), 76.80, 74.96, 72.64, 70.31 (C2-C5), 73.48 (C6), 62.58 (OCH2), 52.85 (C N), 42.97 (CH), 42.35 (CH2 AMA), 37.58 (CH2 AMA), 30.98 (CH-AMA), 14.59 (CH3) ppm. Anal. Calcd. for C20H33NO7 (Mr = 399.48): C 60.13, H 8.33, N 3.51 %; C 59.98, H 8.26, N 3.30 %. Acknowledgments We wish to thank the Ministry of Science, Education and Sports of the Republic of Croatia for support of this work (project 119-1191344-3121). ____________ [1] T. K. 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Received: ((will be filled in by the editorial staff)) Published online: ((will be filled in by the editorial staff)) Entry for the Table of Contents (Please choose one layout) Layout 1: AMA ConjugatesThe preparation of novel glycoconjugates containing 1-adamantamine (AMA) are reported. AMA and its derivatives are of interest since they posess multiple biological properties. Thus, pure - and -anomers of O-mannopyranoside and O-galactopyranoside were prepared and connected to AMA using unnatural chiral linkers. EMBED ChemDraw.Document.6.0 R. Golub, }. Car, V. Petrovi, S. Tomi *& & .. 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