Naslov
Synthesis and Biological Activity of Mannose Conjugates with 1-Adamantamine and Ferrocene Amines

Autori
Ribić, Rosana ; Kovačević, Monika ; Petrović Peroković, Vesna ; Gruić-Sovulj, Ita ; Rapić, Vladimir ; Tomić, Srđanka

Izvornik
Croatica chemica acta (0011-1643) 83 (2010), 4; 421-431

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
o-Mannopyranosides; 1-adamantamine; ferrocene amines; hemagglutination

Sažetak
Pure α- and β-anomers of O-mannosyl conjugates with 1-adamantamine and ferrocene amines were prepared. The sugar moiety in these glycoconjugates is connected to the amine by a chiral linker (methyl (R)-3-hydroxy-2-methyl propanoate and/or methyl (S)-3-hydroxy-2-methyl propanoate). The α-D-mannopyranosides with adamantane and ferrocene aglycon parts were tested using the hemagglutination assay (inhibition of the agglutination of guinea pig erythrocytes by type 1 fimbriated E. coli HB101 (pPKl4)). All glycoconjugates showed inhibitory potencies in the mM range.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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