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Pregled bibliografske jedinice broj: 345956

Inhibition of the Hill reaction by organophosphorus insecticides and simple organic molecules: A QSAR study


Šoškić, Milan
Inhibition of the Hill reaction by organophosphorus insecticides and simple organic molecules: A QSAR study // Abstract book, Fourth international symposium, Computational methods in toxicology and pharmacology integrating internet resources
Moskva, Ruska Federacija, 2007. str. 155-155 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 345956 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Inhibition of the Hill reaction by organophosphorus insecticides and simple organic molecules: A QSAR study

Autori
Šoškić, Milan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract book, Fourth international symposium, Computational methods in toxicology and pharmacology integrating internet resources / - , 2007, 155-155

Skup
Fourth international symposium on computational methods in toxicology and pharmacology integrating internet resources

Mjesto i datum
Moskva, Ruska Federacija, 01.09.2007. - 05.09.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
QSAR; Hill reaction; organophosphorus insecticides; aliphatic acids; aliphatic alcohols; chlorinated benzenes

Sažetak
In an endeavor to accomplish optimal weed control, with a minimum of ecological damage, numerous QSAR studies have been performed for herbicides inhibiting photosynthetic electron transport in chloroplasts (the Hill reaction). There is no such study dealing with plant-protecting agents (e.g. insecticides) which are not intended to target the plant itself. However, in case of inadequate application, even these compounds can exert phytotoxicity. The main objective of this work was to explore in quantitative terms, the interactions of some nonspecific inhibitors of the Hill reaction with isolated chloroplasts. The study encompassed organophosphorus insecticides (which are widely used in agriculture), chlorinated benzenes (important industrial pollutants), n-aliphatic acids (which accumulate in the plants exposed to stress) and n-aliphatic alcohols. Highly significant correlations (as a rule, r > 0.95) between pI20 (the negative logarithm of the concentration causing 20% inhibition of the Hill reaction) and log P (the logarithm of the partition coefficient in the n-octanol/water system) were established for each of the above mentioned groups of compounds. From the obtained regression models, it may be concluded that all four groups of compounds inhibit the Hill reaction by a similar nonspecific mechanism. On the other hand, their inhibitory potencies were somewhat different and increased in the following order: aliphatic acids < aliphatic alcohols < chlorinated benzenes < organophosphorus insecticides. A model comprising all analyzed compounds could be constructed by introducing indicator variables (I = 1 for a particular group of compounds and zero for the others). We also generated, for the more active compounds, a combined model based on pI50 values (negative logarithm of the concentrations which inhibit the Hill reaction by 50%) which facilitated comparisons with published QSAR models for specific inhibitors of the Hill reaction.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA


Projekti:
178-0982929-2259 - Molekulsko prepoznavanje biljnih regulatora rasta (Šoškić, Milan, MZOS ) ( CroRIS)

Ustanove:
Agronomski fakultet, Zagreb

Profili:

Avatar Url Milan Šoškić (autor)


Citiraj ovu publikaciju:

Šoškić, Milan
Inhibition of the Hill reaction by organophosphorus insecticides and simple organic molecules: A QSAR study // Abstract book, Fourth international symposium, Computational methods in toxicology and pharmacology integrating internet resources
Moskva, Ruska Federacija, 2007. str. 155-155 (poster, međunarodna recenzija, sažetak, znanstveni)
Šoškić, M. (2007) Inhibition of the Hill reaction by organophosphorus insecticides and simple organic molecules: A QSAR study. U: Abstract book, Fourth international symposium, Computational methods in toxicology and pharmacology integrating internet resources.
@article{article, author = {\v{S}o\v{s}ki\'{c}, Milan}, year = {2007}, pages = {155-155}, keywords = {QSAR, Hill reaction, organophosphorus insecticides, aliphatic acids, aliphatic alcohols, chlorinated benzenes}, title = {Inhibition of the Hill reaction by organophosphorus insecticides and simple organic molecules: A QSAR study}, keyword = {QSAR, Hill reaction, organophosphorus insecticides, aliphatic acids, aliphatic alcohols, chlorinated benzenes}, publisherplace = {Moskva, Ruska Federacija} }
@article{article, author = {\v{S}o\v{s}ki\'{c}, Milan}, year = {2007}, pages = {155-155}, keywords = {QSAR, Hill reaction, organophosphorus insecticides, aliphatic acids, aliphatic alcohols, chlorinated benzenes}, title = {Inhibition of the Hill reaction by organophosphorus insecticides and simple organic molecules: A QSAR study}, keyword = {QSAR, Hill reaction, organophosphorus insecticides, aliphatic acids, aliphatic alcohols, chlorinated benzenes}, publisherplace = {Moskva, Ruska Federacija} }




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