Naslov
Genotoksični potencijal dentinskih adheziva
(Genotoxic potential of dentin bonding agents)

Autori
Prica, Dunja ; Galić, Nada ; Želježić, Davor ; Prica, Adriana ; Šegović, Sanja

Izvornik
Acta stomatologica Croatica (0001-7019) 41 (2007), 2; 104-114

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
mutageni ; dentinski adhezivi ; kromosomske aberacije
(mutagens ; dentin-bonding agents ; chromosome aberrations)

Sažetak
The aim of this study was to examine the genotoxic activity of five dentin bonding agents: Adper Single Bond, Adper Single Bond 2, Prompt L-pop, Excite and OptiBond Solo Plus. This in vitro study was performed on human lymphocytes from peripheral blood, and the concentrations of dentin bonding agents tested were 0.2, 0.5 i 5 ug/ml, and elution times tested were 1 hour, 24 hours and 5 days. Genotoxicity testing was done using the Structural chromosomal aberration analysis cytogenic method, which determined the complete number of chromosome breaks, chromatide breaks and acentric fragments. The results showed genotoxicity of OptiBond Solo Plus in the 0.2 ug/ml concentration after a 24- hour elution period, then OptiBond Solo Plus in the 0.5 ug/ml concentration after a 1 hour elution period and OptiBond Solo Plus, Adper Single Bond 2 and Excite in the 0.5 ug/ml concentration after a 1 day elution period. In the 5 ug/ml concentration after 1 hour of elution, genotoxic potential was observed in cultures with OptiBond Solo Plus, Excite, Adper Single Bond 2 and Adper Single Bond, while all dentin bonding agents showed genotoxicity at that highest concentration but after 1 day of elution. From the results it is obvious that genotoxicity increases with the concentration of the dentin bonding agent, and decreases over time. The highest genotoxicity was observed after a 24-hour-elution period.

Izvorni jezik
Hrvatski, engleski

Znanstvena područja
Dentalna medicina

POVEZANOST RADA