Pregled bibliografske jedinice broj: 345416
Nasopharyngeal angiofibroma with intracellular accumulation of SPARC – a hypothesis (SPARC in nasopharyngeal angiofibroma)
Nasopharyngeal angiofibroma with intracellular accumulation of SPARC – a hypothesis (SPARC in nasopharyngeal angiofibroma) // Medical Hypotheses, 70 (2008), 3; 600-604 doi:10.1016/j.mehy.2007.06.011 (međunarodna recenzija, članak, znanstveni)
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Naslov
Nasopharyngeal angiofibroma with intracellular accumulation of SPARC – a hypothesis (SPARC in nasopharyngeal angiofibroma)
Autori
Krstulja, Mira ; Car, Alenka ; Bonifačić, David ; Braut, Tamara ; Kujundžić, Milodar
Izvornik
Medical Hypotheses (0306-9877) 70
(2008), 3;
600-604
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
nasopharyngeal; angiofibroma; intracellular; SPARC
Sažetak
Nasopharyngeal angiofibroma is a histologically benign tumor composed of stroma and vessels. The vascular component of the lesion is prone to bleeding and responsible for its clinical ‘ ‘ malignancy’ ’ . Some nasopharyngeal angiofibromas are resistant to surgical therapy because of extensive growth and occasionally bone destruction. It has been shown that molecular factors supporting residual tissue after incomplete surgery might be targeted with pharmacotherapy as a cell based therapy. Because the cell of origin of nasopharyngeal angiofibroma is not recognized yet, it would be of interest to discuss molecule(s) relevant to all the cell components of the growth. Such molecule(s) may also regulate bone homing of the tumor. We propose that in nasopharyngeal angiofibroma the molecule responding to the cues mentioned above is SPARC (secreted protein acidic rich in cystein). We discuss SPARCenabling formation of molecular complexes important for the angiogenic events and present nasopharyngeal angiofibroma as a hyperplastic angiogenic machinery or a ‘ ‘ soil’ ’ without ‘ ‘ seed’ ’ . Therapeutic targeting of SPARC in nasopharyngeal angiofibroma would be targeting of a molecule at the roots of cooperation between stromatogenesis and angiogenesis, coexpressed with Ki67 in the vascular compartment. Considering the intracellular accumulation of SPARC, the benefit of (anti) SPARC therapy in nasopharyngeal angiofibroma is yet to be proved. c 2007 Elsevier Ltd. All rights reserved.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
062-0620095-0083 - Uloga EGFR-a u patogenezi karcinoma larinksa (Manestar, Darko, MZOS ) ( CroRIS)
062-1080315-0243 - Čimbenici zdravlja u primorskom okolišu Hrvatske (Stojanović, Dražen, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka
Profili:
David Bonifačić
(autor)
Milodar Kujundžić
(autor)
Mira Krstulja
(autor)
Tamara Braut
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE