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Pregled bibliografske jedinice broj: 345416

Nasopharyngeal angiofibroma with intracellular accumulation of SPARC – a hypothesis (SPARC in nasopharyngeal angiofibroma)


Krstulja, Mira; Car, Alenka; Bonifačić, David; Braut, Tamara; Kujundžić, Milodar
Nasopharyngeal angiofibroma with intracellular accumulation of SPARC – a hypothesis (SPARC in nasopharyngeal angiofibroma) // Medical Hypotheses, 70 (2008), 3; 600-604 doi:10.1016/j.mehy.2007.06.011 (međunarodna recenzija, članak, znanstveni)


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Naslov
Nasopharyngeal angiofibroma with intracellular accumulation of SPARC – a hypothesis (SPARC in nasopharyngeal angiofibroma)

Autori
Krstulja, Mira ; Car, Alenka ; Bonifačić, David ; Braut, Tamara ; Kujundžić, Milodar

Izvornik
Medical Hypotheses (0306-9877) 70 (2008), 3; 600-604

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
nasopharyngeal; angiofibroma; intracellular; SPARC

Sažetak
Nasopharyngeal angiofibroma is a histologically benign tumor composed of stroma and vessels. The vascular component of the lesion is prone to bleeding and responsible for its clinical ‘ ‘ malignancy’ ’ . Some nasopharyngeal angiofibromas are resistant to surgical therapy because of extensive growth and occasionally bone destruction. It has been shown that molecular factors supporting residual tissue after incomplete surgery might be targeted with pharmacotherapy as a cell based therapy. Because the cell of origin of nasopharyngeal angiofibroma is not recognized yet, it would be of interest to discuss molecule(s) relevant to all the cell components of the growth. Such molecule(s) may also regulate bone homing of the tumor. We propose that in nasopharyngeal angiofibroma the molecule responding to the cues mentioned above is SPARC (secreted protein acidic rich in cystein). We discuss SPARCenabling formation of molecular complexes important for the angiogenic events and present nasopharyngeal angiofibroma as a hyperplastic angiogenic machinery or a ‘ ‘ soil’ ’ without ‘ ‘ seed’ ’ . Therapeutic targeting of SPARC in nasopharyngeal angiofibroma would be targeting of a molecule at the roots of cooperation between stromatogenesis and angiogenesis, coexpressed with Ki67 in the vascular compartment. Considering the intracellular accumulation of SPARC, the benefit of (anti) SPARC therapy in nasopharyngeal angiofibroma is yet to be proved. c 2007 Elsevier Ltd. All rights reserved.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
062-0620095-0083 - Uloga EGFR-a u patogenezi karcinoma larinksa (Manestar, Darko, MZOS ) ( CroRIS)
062-1080315-0243 - Čimbenici zdravlja u primorskom okolišu Hrvatske (Stojanović, Dražen, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Krstulja, Mira; Car, Alenka; Bonifačić, David; Braut, Tamara; Kujundžić, Milodar
Nasopharyngeal angiofibroma with intracellular accumulation of SPARC – a hypothesis (SPARC in nasopharyngeal angiofibroma) // Medical Hypotheses, 70 (2008), 3; 600-604 doi:10.1016/j.mehy.2007.06.011 (međunarodna recenzija, članak, znanstveni)
Krstulja, M., Car, A., Bonifačić, D., Braut, T. & Kujundžić, M. (2008) Nasopharyngeal angiofibroma with intracellular accumulation of SPARC – a hypothesis (SPARC in nasopharyngeal angiofibroma). Medical Hypotheses, 70 (3), 600-604 doi:10.1016/j.mehy.2007.06.011.
@article{article, author = {Krstulja, Mira and Car, Alenka and Bonifa\v{c}i\'{c}, David and Braut, Tamara and Kujund\v{z}i\'{c}, Milodar}, year = {2008}, pages = {600-604}, DOI = {10.1016/j.mehy.2007.06.011}, keywords = {nasopharyngeal, angiofibroma, intracellular, SPARC}, journal = {Medical Hypotheses}, doi = {10.1016/j.mehy.2007.06.011}, volume = {70}, number = {3}, issn = {0306-9877}, title = {Nasopharyngeal angiofibroma with intracellular accumulation of SPARC and \#8211; a hypothesis (SPARC in nasopharyngeal angiofibroma)}, keyword = {nasopharyngeal, angiofibroma, intracellular, SPARC} }
@article{article, author = {Krstulja, Mira and Car, Alenka and Bonifa\v{c}i\'{c}, David and Braut, Tamara and Kujund\v{z}i\'{c}, Milodar}, year = {2008}, pages = {600-604}, DOI = {10.1016/j.mehy.2007.06.011}, keywords = {nasopharyngeal, angiofibroma, intracellular, SPARC}, journal = {Medical Hypotheses}, doi = {10.1016/j.mehy.2007.06.011}, volume = {70}, number = {3}, issn = {0306-9877}, title = {Nasopharyngeal angiofibroma with intracellular accumulation of SPARC and \#8211; a hypothesis (SPARC in nasopharyngeal angiofibroma)}, keyword = {nasopharyngeal, angiofibroma, intracellular, SPARC} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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