Naslov
MTHFR C 677T mutation and 4G/5G PAI-1 polymorphism in patient with polycystic ovarian syndrome

Autori
Radaković, Branko ; Šprem, Marina

Izvornik
Collegium antropologicum (0350-6134) 31 (2007), 3; 919-921

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
PCOS; oral contraceptives; factor V Leiden; prothrombin factor G20210A polymorphism; MTHFR (C677T) mutation; 4G/5G polymorphism PAI-1 gene

Sažetak
Combined oral contraceptives (Ocs) are the most commonly used androgen suppressors and the treatment of choice for menstrual dysfunction in women with polycystic ovarian syndrome (PCOs). Although OCs have remained popular due to their convenience and effectiveness, there have been continuing concerns about adverse effects. The OCs have long been known to incur and increased risk of venous thromboembolism especially in carriers of common inherited thromboembolic defects. Factor V Leiden, prothrombin factor G20210A polymorphism, MTHFR (C677T) mutation and 4G/5G polymorphism of the PAI-1 gene account for the majority of thromboembolic events in association with oral contraceptive use. The aim of the article is to present woman with unrecognized inherited thrombophilia who was treated with OCs due to PCOs signs.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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