Pregled bibliografske jedinice broj: 343981
Progesterone during pregnancy: endocrine-immune cross talk in mammalian species and the role of stress
Progesterone during pregnancy: endocrine-immune cross talk in mammalian species and the role of stress // American Journal of Reproductive Immunology, 58 (2007), 3; 268-279 doi:10.1111/j.1600-0897.2007.00512.x (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 343981 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Progesterone during pregnancy: endocrine-immune cross talk in mammalian species and the role of stress
Autori
Arck, Petra ; Hansen, Peter ; Mulac-Jeričević, Biserka ; Piccinni, Marie-Pierre ; Szekeres-Bartho, Julia
Izvornik
American Journal of Reproductive Immunology (1046-7408) 58
(2007), 3;
268-279
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
NK cells; pregnancy; progesterone
Sažetak
Progesterone is critical for the establishment and the maintenance of pregnancy, both by its endocrine and immunological effects. The genomic actions of progesterone are mediated by the intracellular progesterone receptors ; A and B. A protein called P-induced blocking factor (PIBF), by inducing a TH2 dominant cytokine production, mediates the immunological effects of progesterone. Progesterone plays a role in uterine homing of NK cells and up-regulates HLA-G gene expression, the ligand for various NK inhibitory receptors. At high concentrations progesterone is a potent inducer of Th2-type cytokines as well as of LIF and M-CSF production by T cells. Though a key role for progesterone in creating local immunosuppression has been conserved during the evolution of an epitheliochorial placenta, there has been some divergence in the pattern of endocrine-immunological cross talk in Bovidae. In sheep, uterine serpin, a progesterone-induced endometrial protein, mediates the immunosuppressive effects of progesterone. Epidemiological studies suggest the role of stress in premature pregnancy termination and exposure to stress induces abortion in mice via a significant reduction in progesterone levels, accompanied by reduced serum levels of PIBF. These effects are corrected by progesterone supplementation. These findings indicate the significance of a progesterone-dependent immuno-modulation in maternal tolerance of the fetus, which is discussed in this review.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
062-0620402-0381 - Reprodukcijske i imunološke funkcije progesterona (Mulac-Jeričević, Biserka, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka
Profili:
Biserka Mulac-Jeričević
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- Biological Abstracts/BIOSIS, Elsevier BIOBASE/Current Awareness in Biological Sciences, Science Citation Index, SCISEARCH, Research Alert