Naslov
THE ROLE OF REGULATORY T CELLS (Tregs) IN ENVIRONMENTAL DISEASES

Autori
Mrakovčić-Šutić, Ines ; Bulog, Aleksandar ; Mićović, Vladimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
International Journal on Immunorehabilitation / Sepiashvili RI - Moskva : Meditzina-Zdorov'e, 2008

Skup
World Asthma and COPD Forum

Mjesto i datum
Dubai, Ujedinjeni Arapski Emirati, 26.04.2008. - 29.04.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
urban ait pollution; Tregs; spirometry

Sažetak
Harmony between regulatory T cells (Tregs) and protective immune responses is a subject of great interest of many scientists. Tregs often benefit the host in autoimmune, allergic, infectious diseases as well as in cancer and transplantation. Understanding the mechanisms how the host recognizes countless foreign antigens and remains unresponsive to self have opened many questions in the field of immunological tolerance. The most specific marker that distinguishes regulatory from conventional T cells is forkhead box transcription factor (Foxp 3). Predominant cell types that expressed Foxp 3 are CD4+CD25+ and characteristic of subpopulations which are Foxp 3 negative are their regulatory function lacked. Natural Tregs have the possibility to suppress multiple cell types involved in immunity and inflammation by inhibition the proliferation, immunoglobulin production, the blocking of NK and NKT-cell cytotoxicity, as well as, the function and maturation of dendritic cells. The aim of this study was to examine the effect of urban air pollution on the role of Tregs and compared that with spirometry tests. We characterized immune response, using flow cytometric analysis (FACSCalibur) to determine the phenotypic profile of isolating human peripheral blood lymphocytes of inhabitants living in industrial areas and compared with them living in rural fields. Findings were compared with the control group of healthy volunteers. Results: 59, 1% inhabitants who are living in urban industrial areas have moderate and severe restriction/obstruction spirometry tests, compared to 15% inhabitants from rural areas who have moderate restriction/obstruction spirometry findings. People from industrial areas have statistically significant increased values of Tregs, but in that group those with spirometry’ s changes have decreased number of Tregs. Tregs have the ability to suppress allergic immune response induced by urban air pollution and their role in environmental diseases is marked.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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