Naslov
Gabapentin: effectiveness in headache prophylaxis

Autori
Vuković, Vlasta ; Lovrenčić-Huzjan, Arijana ; Budišić, Mislav ; Demarin, Vida

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Cephalalgia / Goadsby PJ - Oxford : Wiley-Blackwell, 2007, 723-723

Skup
XIII Congress of the International Headache Society

Mjesto i datum
Stockholm, Švedska, 28.06.2007. - 01.07.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
migraine; prophylaxis; gabapentin

Sažetak
Objective: to assess the efficacy and safety of gabapentin in prophylaxis of different types of headache. Methods: A total of 25 patients with headache, 20 female, 5 male (19 migraine-M, 3 cluster headache-CH, 1 posttraumatic headache, 1 hemicrania continua-HC, 1 trigeminal neuralgia-TN) were included in this prospective, open-label study. Patients were given 900-1800 mg of gabapentin in 3 doses ; the follow-up period on average was 6 months. The reduction of days with headache, pain intensity and number of acute medications was assessed. Results: The mean number of migraine days/4weeks was reduced from 15.8 (baseline) to 7.0, a reduction of 8.8 migraine days/4 weeks (p<0.0001). Pain intensity was decreased for > 50% in 7 patients and > 25% in 2 patients. The mean number of headache days/4 weeks in patients with CH and TN was reduced from 28 (baseline) to 8.5, a reduction of 19.5 headache days/4 weeks ; pain intensity was decreased from 25-75 %. A reduction of acute medication use > 50 % was reported. No drug efficacy was reported by 3 patients (12%), 2 M patients and patient with HC. Adverse events (AEs) were reported by 12 patients (48%) ; in 8 patients (32%) the AEs led to discontinuation of the drug. The most frequently reported AEs were drowsiness, dizziness and constipation. Conclusion: If tolerated, prophylactic treatment with gabapentin is associated with significant reduction of headache days and decrease of pain intensity. Gabapentin could be offered as an efficient prophylactic drug in patients with migraine and cluster headache.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA