Naslov
ROLE OF NK AND NKT CELLS IN THE ACTIVATION OF THE INNATE IMMUNE RESPONSE FOLLOWING BURN INJURIES

Autori
Ines Mrakovčić-Šutić, Aleksandra Pirjavec-Mahić, Miljenko Uravić

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
12th Congress of the European Burns Association (EBA) / - , 2007

Skup
12th Congress of the European Burns Association (EBA)

Mjesto i datum
Budimpešta, Mađarska, 12.09.2007. - 15.09.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
burns; NK cells; NKT cells; innate immunity
(burns; NK cells; NKT cells; innate)

Sažetak
Introduction: Burn injuries lead to detrimental changes in immune defence and often are accompanied with hard life-threatening opportunistic infections. Natural killer (NK) and NKT (NKT) cells represent lymphocyte subpopulations with important features in innate immune response. The aim of this study was to determine the effects of burn injuries on expression of NK, NKT cells and other lymphocyte subsets. Methods: Human peripheral blood mononuclear cells from healthy adult volunteers and from patients with burn injuries were taken and labelled with antibodies by direct or indirect staining and analyzed by flow cytometric analysis. Results: Our findings indicate that the percentage of CD19, double staining CD3/CD4, CD3/CD8 and CD5/CD19 positive cells are significantly decreased in peripheral blood of burned patients, while the percentage of NKT cells has shown significant augmentation. Conclusions: The immunoregulatory functions of NKT cells in burn injuries are marked and we are able to discuss NKT cell based immunotherapeutic strategies.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA