Naslov
Moderating activities of regulatory T (Treg) and NKT cells on innate immunity in chronic exposure to vapors

Autori
Ines Mrakovčić-Šutić, Aleksandar Bulog, Vladimir Mićović

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Immuno Rio 2007, 13th International Congress of Immunology / - , 2007

Skup
13th International Congress of Immunology, Rio de Janeiro, Brazil

Mjesto i datum
Rio de Janeiro, Brazil, 21.08.2007. - 25.08.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
NKT cells; Tregs; environmental diseases; innate immunity

Sažetak
The ability of extracellular stimuli to modulate innate immunity via dendritic cell (DC) activation of natural killer T (NKT) cells are still poor understood. Natural killer (NK) and NKT cells are important in innate immune defense. Their activity plays a crucial role in the regulation of peripheral tolerance, and in autoimmune, antitumor, allergic and antimicrobial immune response. The immune system's capacity to distinguish between innocuous and harmful foreign antigens is controlled by mechanisms of central and peripheral tolerance. Mechanisms of peripheral tolerance involve the induction of cell death or the development of a non-responsive state (anergy) of T cells. Regulatory T (Treg) cells have active suppression mode and may induce peripheral tolerance. These immunoregulatory mechanisms of Treg cells are the subject of intensive investigation. Dendritic cells (DCs) maturation and/or activation are important in the induction of peripheral tolerance and may control peripheral tolerance inducing the differentiation of Treg cells. In this study, we attempted to analyze the characteristics of human regulatory T cells and NKT cells, using a flow cytometric technique (FACSCalibur) for detecting phenotype profiles of isolating human peripheral blood lymphocytes (PBL) of people leave near gasoline industry. Control group was formed of healthy volunteers. The results were analysed using computer programs Sigma Plot for Windows, version 1.02 and Statistica 7.1. Our data have shown that the chronic inhalation exposures significantly increase the percentage of NKT cells, which may interplay with the number and function of Treg and dendritic cells.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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