Naslov
Bone loss in the course fo three years after kidney transplantation.

Autori
Smalcelj, Ruzica ; Kusec, Vesna ; Kes, Petar

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Calciffied Tissue International / - , 2007

Skup
34th European Symposium on Calcified Tissues

Mjesto i datum
Kopenhagen, Danska, 05.05.2007. - 09.05.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
bone markers; bone metabolism; renal osteodystrophy

Sažetak
Chronic kidney failure is deleterious for the skeletal integrity. Successful kidney transplantation corrects most metabolic disorders, but hyperparathyroidism might persist for two or more years. Bone turnover may be increased in this period and the rate of bone loss variable. The aim of this investigation was follow-up of bone mass after kidney transplantation. This study comprised 86 kidney transplant recipients (52 men, 34 women, 43.9+/-10.4 years) with stable kidney function monitored by densitometry of the lumbar spine, left hip and forearm. Measurements were performed 2 &#8211; 4 times in various post-transplant intervals between 1 and 40 months (13.03&plusmn ; ; 11.15). No difference between sexes existed for age, hemodialysis duration, creatinine and initial T-scores in the first six post-transplant months. Densitometry data was analysed for the entire patient group, according to post-transplant periods: <6 months (first), 7-12 months (second), 13-24 months (third) and >25 months (fourth). Osteopenia (T-score<1) in the lumbar and hip region was present in 50% and for the forearm in 74% of patients in the first six months after transplantation. In the second post-transplant year osteopenia of the lumbar spine and hip was greater than 65%, but did not change for the forearm. Forearm T-scores were significantly lower than in the spine and hip, except for the femur in the second period. Spine and hip T-scores did not differ, except in the fourth period (p<0.04) with greater bone loss in the spine. No correlation of T-scores existed with post-transplant period. Paired T-test showed statistically significant decrease of initial T-scores in the second (<0.0005), third (p<0.0005) and fourth post-transplant period (p<0.001) for the lumbar spine ; the second (p<0.001) and third (p<0.002) period for the hip ; and for the third (p<0.002) and fourth (p<0.0005) period for the forearm. Only for the forearm, a statistically significant decrement was also found between the third and fourth period (p<0.003). These results indicate that bone loss proceeds after kidney transplantation within the follow-up period of three years. Decrease of bone mass was more pronounced in the first year and continues at a slower rate in the later period. The degree of bone loss is similar for the spine and hip in the first two post-transplant years, but significantly greater for the forearm. This study stresses the increased risk of osteoporosis in kidney transplant recipients irrespective of sex.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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