Naslov
Pericyte/myofibroblast phenotype of osteoprogenitor cell

Autori
Kalajzić, Ivo ; Kalajzić, Žana ; Wang, L. ; Jiang, X. ; Lamothe, K. ; San Miguel, S.M. ; Aguila, H.L. ; Rowe, D.W.

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Journal of musculoskeletal and neuronal interactions / Webster S.S. Jee, Salt Lake City (U.S.A.), George P. Lyritis, Athens - Lahti : Kifissia, Greece : Society of Musculoskeletal and Neuronal Interactions, 2007, 320-322

Skup
37th International Sun Valley Workshop

Mjesto i datum
Sjedinjene Američke Države, 05.08.2007. - 08.08.2007

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
osteoblasts; differentiation; gene targeting

Sažetak
The osteoblast lineage arises from a mesenchymal progenitor cell that also has the ability to generate a diversity of other lineages including adipocytes, chondrocytes, myocytes and cells that support hematopoiesis1, 2. In order to better understand the developmental and homeostatic processes in bone it is imperative to define strictly the stages within the osteoprogenitor lineage maturation. The development of experimental models in which green fluorescent protein (GFP) reporter genes are expressed under the control of osteoblast lineage promoters has provided valuable information on the progression of the lineage at relatively mature stages of development. However, they have not provided information on the identity of mesenchymal progenitor cells prior to entering the osteogenic pathway. We propose that the step of recruitment of multipotent progenitors into the osteogenic pathway is a critical stage on the control of bone mass and could be an attractive target for pharmacological intervention. Unfortunately, at this moment we do not possess good strategies to confidently identify and isolate these early progenitors. Based on the successful development of osteoblast lineage directed GFP markers, we now aim to identify a definitive marker specific for progenitor cells prior to entering the osteogenic pathway.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA