Naslov
Mechanism of absorbtion of the cerebrospinal fluid

Autori
Bulat, Marin ; Lupret, Velimir ; Orešković, Darko ; Klarica, Marijan

Izvornik
Periodicum biologorum (0031-5362) 109 (2007), 2; 124-124

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
mechanism ; absorbtion ; CSF

Sažetak
Introduction: It is generally accepted that volume of cerebrospinal fluid (CSF) is secreted in brain ventricles and flows to subarachnoid space to be absorbed into dural venous sinuses or/and into lymphatics via perineural sheats of cranial nerves. Methods and Results: Since 99% of CSF volume is water, in experiments on cats 3H-water was slowly infused into lateral ventricle and found that it does not flow to subarachnoid space but that it is rapidly absorbed transventricularly into periventricular capillaries. When 3H-water was infused in cortical subarachnoid space, it was absorbed locally into cerebral capillaries via pia mater. On the contrary, when macromolecule 3H-inulin is applied in CSF, it is very slowly eliminated in bloodstream, and, with time, is carried by systolic-diastolic pulsations and mixing of CSF bidirectionally along CSF system. Conclusions: These data indicate that CSF volume (water) is absorbed rapidly into adjacent cerebral capillaries while inulin is distributed bidirectionally due to its long residence time in CSF. Previously, the macromolecules have been used to study CSF volume hydrodynamics and with this misconception of CSF physiology arose.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA