Naslov
Integrated gene networks in breast cancer development

Autori
Ratkaj, Ivana ; Štajduhar, Emil ; Vučinić, Srđan ; Spaventi, Šime ; Pavelić, Krešimir ; Bošnjak, Hrvojka ; Kraljević Pavelić, Sandra

Izvornik
Functional & integrative genomics (1438-793X) 10 (2010), 1; 11-19

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
breast cancer ; metastasis ; functional genomics

Sažetak
Breast cancer is a complex and heterogenous disease. Classical molecular medical approaches cannot fully understand and comprehend its pathogenesis. In this review, the development of new biological markers for the early detection and creation of guided and specific therapy of breast cancer are discussed in light of the rapid advances in the "omics". Results of cancer research in combination with large-scale methods that examine the expression status of genes and proteins have identified a large number of new biomarkers as well as confirmed the human growth hormone as an important player in the pathogenesis of this disease through its autocrine regulation where it influences the activation of Pax5 and HOXA1 gene networks.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA