Naslov
Transcriptional expression and functional activity of mu-opioid receptors (MOR) on myelo-monocytic HL-60 cell line

Autori
Gabrilovac, Jelka ; Breljak, Davorka ; Čupić, Barbara

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
8th International Congress of Neuroimmunology Free Papers / Takashi, Tabira ; Takashi, Yamamura ; Junichi, Kira - Bolonja : Monduzzi Editore S.p.A. - Medimond Inc., International Proceedings Division, 2007, 287-292

ISBN
978-88-7587-324-0

Skup
8th International Conference of Neuroimmunology : (ISNI 2006)

Mjesto i datum
Nagoya, Japan, 15.10.2006. - 19.10.2006

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
mu-opioid receptors ; transcriptional expression ; functional activity ; morphine ; endomorphin-2

Sažetak
Opioid receptors, highly expressed on cells of central nervous system, were also found on cells of hematopoietic origin, but at much lower density. In this study we have examined transcriptional expression of mu-opioid receptors (MOR) on HL-60 cells of myelo-monocytic origin, at their basal state. Functionality of the MOR on these cells was examined by following Ca++ mobilization triggered by selective agonist of alkaloid (morphine) and peptide (endomorphin-2) structure. The data obtained have shown that cells of myelo-monocytic HL-60 line, at their basal state, express MOR both at the level of mRNA and at the level of a functionally active protein capable of transmitting intracellular signals via Ca++ upon ligation with selective agonists of alkaloid or peptide structure.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA