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Pregled bibliografske jedinice broj: 334968

Genomic damage in children accidentally exposed to ionizing radiation: A review of the literature

Fučić, Aleksandra; Brunborg, G.; Lasan, Ružica; Ježek, Davor; Knudsen, L. E.; Merlo, D. F.
Genomic damage in children accidentally exposed to ionizing radiation: A review of the literature // Mutation Research - Reviews in Mutation Research, 658 (2008), 1-2; 111-123 doi:10.1016/j.mrrev.2007.11.003 (međunarodna recenzija, pregledni rad, znanstveni)

CROSBI ID: 334968 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Genomic damage in children accidentally exposed to ionizing radiation: A review of the literature

Autori
Fučić, Aleksandra ; Brunborg, G. ; Lasan, Ružica ; Ježek, Davor ; Knudsen, L. E. ; Merlo, D. F.

Izvornik
Mutation Research - Reviews in Mutation Research (1383-5742) 658 (2008), 1-2; 111-123

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
children; radiation; chemical agents

Sažetak
During the last decade, our knowledge of the mechanisms by which children respond to exposures to physical and chemical agents present in the environment, has significantly increased. Results of recent projects and programmes focused on children's health underline a specific vulnerability of children to environmental genotoxicants. Environmental research on children predominantly investigates the health effects of air pollution while effects from radiation exposure deserve more attention. The main sources of knowledge on genome damage of children exposed to radiation are studies performed after the Chernobyl nuclear plant accident in 1986. The present review presents and discusses data collected from papers analyzing genome damage in children environmentally exposed to ionizing radiation. Overall, the evidence from the studies conducted following the Chernobyl accident, nuclear tests, environmental radiation pollution and indoor accidental contamination reveals consistently increased chromosome aberration and micronuclei frequency in exposed than in referent children. Future research in this area should be focused on studies providing information on: (a) effects on children caused by low doses of radiation ; (b) effects on children from combined exposure to low doses of radiation and chemical agents from food, water and air ; and (c) specific effects from exposure during early childhood (radioisotopes from water, radon in homes). Special consideration should also be given to a possible impact of a radiochemical environment to the development of an adaptive response for genomic damage. Interactive databases should be developed to provide integration of cytogenetic data, childhood cancer registry data and information on environmental contamination. The overall aim is to introduce timely and efficient preventive measures, by means of a better knowledge of the early and delayed health effects in children resulting from radiation exposure.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Projekti:
022-0222148-2137 - Genotoksičnost kemijskih i fizikalnih agensa prirodnog i antropogenog podrijetla (Kašuba, Vilena, MZOS ) ( CroRIS)
108-1080399-0335 - Eksperimentalni embrionalni tumori i razvoj zametaka sisavaca in vitro i in vivo (Jakuš, Florijana, MZOS ) ( CroRIS)
108-1080399-0383 - Muški i ženski spolni sustav: razvoj, normalna histofiziologija i neplodnost (Ježek, Davor, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Ružica Lasan Trčić (autor)

Avatar Url Davor Ježek (autor)

Avatar Url Aleksandra Fučić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Fučić, Aleksandra; Brunborg, G.; Lasan, Ružica; Ježek, Davor; Knudsen, L. E.; Merlo, D. F.
Genomic damage in children accidentally exposed to ionizing radiation: A review of the literature // Mutation Research - Reviews in Mutation Research, 658 (2008), 1-2; 111-123 doi:10.1016/j.mrrev.2007.11.003 (međunarodna recenzija, pregledni rad, znanstveni)
Fučić, A., Brunborg, G., Lasan, R., Ježek, D., Knudsen, L. & Merlo, D. (2008) Genomic damage in children accidentally exposed to ionizing radiation: A review of the literature. Mutation Research - Reviews in Mutation Research, 658 (1-2), 111-123 doi:10.1016/j.mrrev.2007.11.003.
@article{article, author = {Fu\v{c}i\'{c}, Aleksandra and Brunborg, G. and Lasan, Ru\v{z}ica and Je\v{z}ek, Davor and Knudsen, L. E. and Merlo, D. F.}, year = {2008}, pages = {111-123}, DOI = {10.1016/j.mrrev.2007.11.003}, keywords = {children, radiation, chemical agents}, journal = {Mutation Research - Reviews in Mutation Research}, doi = {10.1016/j.mrrev.2007.11.003}, volume = {658}, number = {1-2}, issn = {1383-5742}, title = {Genomic damage in children accidentally exposed to ionizing radiation: A review of the literature}, keyword = {children, radiation, chemical agents} }
@article{article, author = {Fu\v{c}i\'{c}, Aleksandra and Brunborg, G. and Lasan, Ru\v{z}ica and Je\v{z}ek, Davor and Knudsen, L. E. and Merlo, D. F.}, year = {2008}, pages = {111-123}, DOI = {10.1016/j.mrrev.2007.11.003}, keywords = {children, radiation, chemical agents}, journal = {Mutation Research - Reviews in Mutation Research}, doi = {10.1016/j.mrrev.2007.11.003}, volume = {658}, number = {1-2}, issn = {1383-5742}, title = {Genomic damage in children accidentally exposed to ionizing radiation: A review of the literature}, keyword = {children, radiation, chemical agents} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus

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