Naslov
Nociception and brain serotonin following single intraperitoneal injection and long lasting peroral glucose intake in rats

Autori
Šalković-Petrišić, Melita ; Bonassin, Corrado ; Lacković, Zdravko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Naunyn-Schmiedberg's Archiver of Pharmacology XIIIth International Congress of Pharmacology / Gothert, M ; Jakobs KH - Berlin : Springer, 1998, R79-R79

Skup
XIIIth International Congress of Pharmacology

Mjesto i datum
München, Njemačka, 26.07.1998. - 31.07.1998

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
glucose; brain serotonin; nociception

Sažetak
The influence of elevated glucose intake on nociception has been investigated mostly in hyperglycemic, diabetic rats or in healthy rats fey hours following a single glucose application. We have investigated the time (up to 4 weeks) and the dose (0.1-1 M) response of a single intraperitoneal /i.p./ injection of glucose and the influence of 1 week lasting peroral /p.o./ 0.2 M glucose on nociception in healthy rats. Pain threshold has been determined as the tail flick latency in tail immersion test at the 55 *C. Brain serotonin (5-HT) and its metabolite, 5-hydroxyindoleacetic acid (5-HIAA) have been measured spectrophotofluorimetrically. Following a single i.p. injection of 0.2M glucose pain threshold rises and remains elevated up to 3 weeks posttreatment (20-70%), with an increase being dose dependent at the 2nd and 7th day following 0.2, 0.5 and 1M glucose i.p. injection 832-83%), respectively. Increased pain threshold has also been found at the 1st (79%) and 7th day (43%) following the continuous p.o. intake of 0.2M glucose. In rats kept on 0.M glucose p.o. intake for 7 days the content of brain 5-HT, possible modulator of nociception is decreased (-33%), while the 5-HIAA content is increased (20%). 7 days following single i.p. injection of 0.2M glucose the content of brain 5-HIAA is increased (19%), as well. Unchanged or mildly decreased blood glucose levels in glucose treated animals suggest that altered nociception may be related to glucose-induced insulin secretion and/or altered brain 5-HT transmission, at least in long lasting glucose p.o. treated rats.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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