Pregled bibliografske jedinice broj: 333732
Differential effect of high dietary iron on alpha-tocopherol and retinol levels in the liver and serum of mice fed olive oil– and corn oil– enriched diets
Differential effect of high dietary iron on alpha-tocopherol and retinol levels in the liver and serum of mice fed olive oil– and corn oil– enriched diets // Nutrition Research, 28 (2008), 4; 263-269 doi:10.1016/j.nutres.2008.01.007 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 333732 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Differential effect of high dietary iron on alpha-tocopherol and retinol levels in the liver and serum of mice fed olive oil– and corn oil– enriched diets
Autori
Domitrović, Robert ; Tota, Marin ; Milin, Čedomila
Izvornik
Nutrition Research (0271-5317) 28
(2008), 4;
263-269
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
olive oil; corn oil; diet; iron; retinol; alpha-tocopherol; TBARS; mice
Sažetak
The influence of dietary fats on cellular alpha-tocopherol and retinol uptake in iron overload is poorly understood. The aim of this study was to investigate the effect of a high-iron diet on the retinol and alpha-tocopherol levels in mice fed olive oil– and corn oil– enriched diets. Mice were fed for 3 weeks a standard mouse chow (the control group) and diets enriched with 5% by weight of corn oil or olive oil. Diets of the mice fed corn oil and olive oil were additionally supplemented with 1% by weight carbonyl iron. Both dietary oils and iron increased the liver iron uptake. High-iron feeding induced oxidative stress in mice liver, measured as a thiobarbituric acid-reactive substance level. Both fats and iron induced changes in the liver fatty acid composition. Liver retinol and alpha-tocopherol stores increased with iron supplementation in the olive oil– enriched diet, with a simultaneous decrease in serum. The results suggest that the influx of alpha-tocopherol and retinol from serum to the liver is induced by high dietary iron. This redistribution appears to be stronger for retinol than for alpha-tocopherol and is also higher in mice fed olive oil than in mice fed corn oil, suggesting that the composition of dietary lipids is important in the treatment of high-iron tissue conditions. In conclusion, the results of this study suggest that the increase of hepatic alpha-tocopherol and retinol levels in the olive oil– based diet is a dietary-dependent responsive mechanism that probably is not primarily related to an increased risk of oxidative damage induced by high-iron intake.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
062-0621341-0061 - Masne kiseline i polifenoli u regeneraciji i reparaciji tkiva. (Milin, Čedomila, MZOS ) ( CroRIS)
062-0000000-3554 - Aktivni sastojci ljekovitog bilja u terapiji fibroze jetre (Domitrović, Robert, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- EMBASE (Excerpta Medica)
- BIOMED
- Elsevier BIOBASE
- SCISEARCH
- Scopus
