Naslov
Abnormal systolic blood pressure during treadmill test and brachial artery flow-mediated vasodilatation impairment

Autori
Mirat, Jure ; Bernat, Robert ; Majdančić, Z. ; Kolčić, Ivana ; Galić, Edvard ; Zeljko, H. ; Bergovec, Mijo ; Reiner, Željko

Izvornik
Collegium Antropologicum (0350-6134) 31 (2007), 2; 517-522

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
systolic blood pressure; tredmill test; brachial artery; flow-mediated vasodilatation impairment

Sažetak
The aim of the study was to assess the relationship between systolic blood pressure during maximal treadmill test (SBPmtt) and flow-mediated vasodilation (FMD). Abnormal rise of SBPmtt is the phenomenon more frequent in hypertensive persons but it could be found in normotensive subjects too. 199 subjects referred to treadmill test were enrolled in the study. Four groups were formed: hypertensives with abnormal SBPmtt (group A), hypertensives with normal SBPmtt, (group B), normotensives with abnormal SBPmtt (group C) and normotensiues with normal SBPmtt (group D). Rise of SBPmtt above 200 mmHg was considered abnormal reaction. Simple linear regression analysis showed significant inverse relationship between SBPmtt and FMD (F=20.2036, p < 0.001, R2= 0.0956). Mean FMD index was worst in hypertensive subjects with abnormal SBPmtt (group A), followed by normotensiues with abnormal SBPmtt (group C), hypertensives with normal SBPmtt (group B) and the best was in normotensiues with normal SBPmtt (3.56 +/- 5.17, 4.19 +/- 5.14, 6.81 +/- 8.43 and 10.92 +/- 7.48%, respectively). In multivariate regression analysis FMD showed significant association with abnormal SBPmtt (p < 0.001) along with brachial artery diameter (p < 0.001), male gender (p < 0.001), but not with hypertension (p=0.073), BMI (p=0.137) and total cholesterol (p=0.23) (coefficients: -0.26, -0.40, -0.27, -0.13, -0.11 and -0. 0 7, respectively). There was a significant inverse relationship between SBPmtt and FMD. An impairment of FMD exists in normotensive subjects with abnormal SBPmtt. In hypertensives with abnormal SBPmtt an additional impairment of FMD exists when compared to hypertensives with normal SBPmtt. Abnormal SBPmtt should be taken into account in global cardiovascular risk assessment.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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