Naslov
Deletion polymorphism of the angiotensin I- converting enzyme gene in elderly patients with coronary heart disease

Autori
Bergman Marković, Biserka ; Bergovec, Mijo ; Reiner, Željko ; Sertić, Jadranka ; Vincelj, Josip ; Marković, Maja

Izvornik
Collegium Antropologicum (0350-6134) 31 (2007), 1; 179-183

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
polymorphism ACE gene ; ACE activity ; CHD ; elderly

Sažetak
Controversy exist at to whether the deletion/deletion(DD)genotype of angiotensin l- converting enzyme(ACE)gene polymorphism is associated with coronary heart disease CHD).There are only a few studies dealing with this issue in the elderly, also with controversial results. The aim of this study was the assessment of correlation between genetic markers and the risk of CHD in the elderly.The results indicated DD genotype importance for CHD in the elderly as proven by discriminant analysis(x2=25.77 ; df=16 ; p=0.0620).However, the use of univariate method demonstrated no correlation between DD genotype of ACE gene polymorphism and coronary artery disease.D allele of ACE gene was associated with higher activities of ACE plasma.A weak, but increased risk of MI is associated with high frequency of DD genotype in the elderly

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA