Naslov
Antibiotic resistance mechanisms in bacteria: biochemical and genetic aspects

Autori
Džidić, Senka ; Šušković, Jagoda ; Kos, Blaženka

Izvornik
Food Technology and Biotechnology (1330-9862) 46 (2008), 1; 11-21

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
antibiotic resistance; multidrug resistance; antibiotic inactivation; target modification; drug efflux; membrane permeability changes hypermutators; horizontal gene transfer
(antibiotic resistance; multidrug resistance; antibiotic inactivation; target modification; drug efflux; membrane permeability changes hypermutators; horizontal gene transfe)

Sažetak
Since the discovery and subsequent widespread use of antibiotics, a variety of bacterial species of human and animal origin have developed numerous mechanisms that render bacteria resistant to some, and in certain cases to nearly all antibiotics. There are many important pathogens that are resistant to multiple antibiotic classes, and infections caused by multidrug resistant (MDR) organisms are limiting treatment options and compromising effective therapy. So the emergence of antibiotic resistant pathogens in bacterial populations is a relevant field of study in molecular and evolutionary biology and in medical practice. There are two main aspects to the biology of antimicrobial resistance. One is concerned with the development, acquisition and spread of the resistance gene itself. The other is the specific biochemical mechanism conveyed by this resistance gene. In this review we present some recent data on molecular mechanisms of antibiotic resistance.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija

POVEZANOST RADA