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Pregled bibliografske jedinice broj: 327559

Gamma-glutamyltransferase activity and total antioxidant status in serum and platelets of patients with community-acquired pneumonia

Laškaj, Renata; Dodig, Slavica; Čepelak, Ivana; Kuzman, Ilija.
Gamma-glutamyltransferase activity and total antioxidant status in serum and platelets of patients with community-acquired pneumonia // Archives of Medical Resear, 38 (2007), 424-431 doi:10.1016/j.arcmed.2007.01.005 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 327559 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Gamma-glutamyltransferase activity and total antioxidant status in serum and platelets of patients with community-acquired pneumonia

Autori
Laškaj, Renata ; Dodig, Slavica ; Čepelak, Ivana ; Kuzman, Ilija.

Izvornik
Archives of Medical Resear (0188-4409) 38 (2007); 424-431

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Community-acquired pneumonia; Gamma-glutamyltransferase; Thrombocytosis; Total antioxidative status; Platelets

Sažetak
We undertook this study to analyze serum and platelet gamma-glutamyltransferase (GGT) activity and total antioxidant status (TAS) concentration during the course of pneumonia and to compare them between patients with normal platelet count and those who developed reactive thrombocytosis. METHODS: Platelet count, GGT activity and TAS concentration in serum (S) and platelet (Plt) isolates were measured in 60 patients with community-acquired pneumonia (CAP) on admission and at discharge. RESULTS: At the end of treatment, platelet count increased significantly from the value recorded on admission. By the end of treatment, 42% of patients developed reactive thrombocytosis. Serum and platelet GGT activity was higher, whereas (S)TAS was significantly lower in CAP patients than in control subjects. On admission, (Plt)TAS was significantly higher in CAP patients as compared with control subjects ; at discharge, (Plt)TAS was lower in comparison with either patient admission and control subjects. GGT activity and TAS concentration in serum and platelet isolate on admission did not differ significantly between patients with and without thrombocytosis. At discharge, (S)GGT activity showed no significant changes, whereas (Plt)GGT decreased significantly in patients with thrombocytosis as compared with those without thrombocytosis. In patients with thrombocytosis, (S)TAS concentration showed no significant difference, whereas (Plt)TAS concentration measured at discharge was significantly lower in patients with thrombocytosis as compared to those with normal platelet count. CONCLUSIONS: The pattern of changes in (Plt)GGT catalytic activity and TAS concentration might be indicative of a certain role of thrombocytosis during treatment in patients with CAP. Further investigations are necessary to clarify these changes.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
006-0061245-0977 - Molekularni mehanizmi patogeneze kronične opstrukcijske bolesti pluća (Žanić-Grubišić, Tihana, MZOS ) ( CroRIS)
277-2770966-0965 - Kondenzat izdaha kao izvor biomarkera plućnih bolesti u djece (Dodig, Slavica, MZOS ) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Ivana Čepelak (autor)

Avatar Url Slavica Dodig (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Laškaj, Renata; Dodig, Slavica; Čepelak, Ivana; Kuzman, Ilija.
Gamma-glutamyltransferase activity and total antioxidant status in serum and platelets of patients with community-acquired pneumonia // Archives of Medical Resear, 38 (2007), 424-431 doi:10.1016/j.arcmed.2007.01.005 (međunarodna recenzija, članak, znanstveni)
Laškaj, R., Dodig, S., Čepelak, I. & Kuzman, I. (2007) Gamma-glutamyltransferase activity and total antioxidant status in serum and platelets of patients with community-acquired pneumonia. Archives of Medical Resear, 38, 424-431 doi:10.1016/j.arcmed.2007.01.005.
@article{article, author = {La\v{s}kaj, Renata and Dodig, Slavica and \v{C}epelak, Ivana and Kuzman, Ilija.}, year = {2007}, pages = {424-431}, DOI = {10.1016/j.arcmed.2007.01.005}, keywords = {Community-acquired pneumonia, Gamma-glutamyltransferase, Thrombocytosis, Total antioxidative status, Platelets}, journal = {Archives of Medical Resear}, doi = {10.1016/j.arcmed.2007.01.005}, volume = {38}, issn = {0188-4409}, title = {Gamma-glutamyltransferase activity and total antioxidant status in serum and platelets of patients with community-acquired pneumonia}, keyword = {Community-acquired pneumonia, Gamma-glutamyltransferase, Thrombocytosis, Total antioxidative status, Platelets} }
@article{article, author = {La\v{s}kaj, Renata and Dodig, Slavica and \v{C}epelak, Ivana and Kuzman, Ilija.}, year = {2007}, pages = {424-431}, DOI = {10.1016/j.arcmed.2007.01.005}, keywords = {Community-acquired pneumonia, Gamma-glutamyltransferase, Thrombocytosis, Total antioxidative status, Platelets}, journal = {Archives of Medical Resear}, doi = {10.1016/j.arcmed.2007.01.005}, volume = {38}, issn = {0188-4409}, title = {Gamma-glutamyltransferase activity and total antioxidant status in serum and platelets of patients with community-acquired pneumonia}, keyword = {Community-acquired pneumonia, Gamma-glutamyltransferase, Thrombocytosis, Total antioxidative status, Platelets} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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