Effects of human isolation and inbreeding on human quantitative traits : An example of biochemical markers of hemostasis and inflammation

Pulanić, Dražen; Polašek, Ozren; Petrovečki, Mladen; Vorko-Jović, Ariana; Peričić, Marijana; Barać Lauc, Lovorka; Martinović Klarić, Irena; Biloglav, Zrinka; Kolčić, Ivana; Zgaga, Lina; Carothers, Andrew D.; Ramić, Senad; Šetić, Mia; Janićijević, Branka; Smolej Narančić, Nina; Bučan, Kajo; Rudan, Diana; Lowe, Gordon; Rumley, Ann; Rudan, Pavao; Campbell, Harry; Rudan, Igor

Pregled bibliografske jedinice broj: 327266

Effects of human isolation and inbreeding on human quantitative traits : An example of biochemical markers of hemostasis and inflammation

Pulanić, Dražen; Polašek, Ozren; Petrovečki, Mladen; Vorko-Jović, Ariana; Peričić, Marijana; Barać Lauc, Lovorka; Martinović Klarić, Irena; Biloglav, Zrinka; Kolčić, Ivana; Zgaga, Lina et al.

Effects of human isolation and inbreeding on human quantitative traits : An example of biochemical markers of hemostasis and inflammation // Human biology, 80 (2008), 5; 513-533 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 327266 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Effects of human isolation and inbreeding on human quantitative traits : An example of biochemical markers of hemostasis and inflammation

Autori
Pulanić, Dražen ; Polašek, Ozren ; Petrovečki, Mladen ; Vorko-Jović, Ariana ; Peričić, Marijana ; Barać Lauc, Lovorka ; Martinović Klarić, Irena ; Biloglav, Zrinka ; Kolčić, Ivana ; Zgaga, Lina ; Carothers, Andrew D. ; Ramić, Senad ; Šetić, Mia ; Janićijević, Branka ; Smolej Narančić, Nina ; Bučan, Kajo ; Rudan, Diana ; Lowe, Gordon ; Rumley, Ann ; Rudan, Pavao ; Campbell, Harry ; Rudan, Igor

Izvornik
Human biology (0018-7143) 80 (2008), 5; 513-533

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
humans; genome-wide heterozygosity; biochemical markers of hemostasis and inflammation

Sažetak
Genome-wide multilocus heterozygosity (MLH) can have considerable effects on biological quantitative traits, especially those that are highly polygenically determined or mediated by rare genetic variants. We investigated the effects of MLH on biochemical markers of hemostasis and inflammation in 1, 041 individuals from the island of Vis, Croatia, where consanguinity is prevalent and there is a wide range of MLH values in the population. Assessment of MLH was based on genome-wide scans using 800 microsatellite (STR) and 317, 000 single nucleotide (SNP) polymorphic markers in each examinee. Additionally, for each individual we defined ?personal genetic history? (PGH) based on genealogical records. The association between PGH and MLH and fibrinogen, D-dimer (Dd), von Willebrand factor (vWF), tissue plasminogen activator (t-PA) and C-reactive protein (CRP) was performed with multiple linear regression, while controlling for possible confounding effects. PGH was a significant predictor only for tPA (P<0.001), while neither of the two MLH measures exhibited significant association with any of the investigated traits. Fib was mainly predicted by age and body mass index (P<0.001) ; Dd and vWF by age (P<0.001) and albumin (P=0.004) ; tPA by age, gender, body mass index and triglycerides (P<0.001) ; and CRP by gender, body mass index, albumin and forced expiratory volume in the 1st second (P<0.001). Weak associations between PGH and MLH and markers of hemostasis and inflammation suggest that their genetic control may not be highly polygenic and that they could represent promising targets for genetic association studies.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA

Projekti:
108-1080315-0255 - Rizici za višekratne nesreće među ozlijeđenima na bolničkom liječenju (Vorko-Jović, Ariana, MZOS ) ( CroRIS)
196-1962766-2747 - Kompleksna obilježja i zdravlje stanovništva od djetinjstva do duboke starosti (Smolej-Narančić, Nina, MZOS ) ( CroRIS)
196-1962766-2751 - Populacijska struktura Hrvatske - antropogenetički pristup (Rudan, Pavao, MZOS ) ( CroRIS)
196-1962766-2763 - Molekularno-genetička obilježja populacija utemeljitelja - Romi kao model (Janićijević, Branka, MZOS ) ( CroRIS)
198-1080315-0292 - Nasljedne i okolišne odrednice duboke starosti - hrvatski stogodišnjaci (Rudan, Diana, MZOS ) ( CroRIS)
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Polašek, Ozren, MZOS ) ( CroRIS)