Naslov
Evolutional pattern of gangliosides expression in spinal cord

Autori
Mojsović, Ana ; Peternel, Hrvoje ; Đikić, Domagoj ; Schnaar, Ronald ; Heffer Lauc, Marija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
1. hrvatski kongres za molekularne bioznanosti uz međunarodno sudjelovanje : knjiga sažetaka = 1st Croatian Congress on Molecular Life Sciences with international participation : book of abstracts / Dumić, Jerka - Zagreb : Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2002, 152-152

ISBN
953-6256-13-4

Skup
Hrvatski kongres za molekularne bioznanosti uz međunarodno sudjelovanje (1 ; 2002)

Mjesto i datum
Opatija, Hrvatska, 09.06.2002. - 13.06.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
ganglisides; evolution; spinal cord

Sažetak
Using highly specific anti-gangliosides antibodies of IgG class we reconstructed cellular distribution of major gangliosides in human, cat, rabbit, rat, mouse, chicken, parrot, turtle, lizard, frog and fish spinal cord. We have not detected any of four structures in fish or frog spinal cord. Lizard express GD1a, GD1b and GT1b mostly in white matter. White matter expression of major gangliosides prevails also in turtle, but it turns into gray matter pattern in chicken and higher animals continuing till humans. Drastic change from fiber into more cell-body expression is probably connected with different functions attributed to same structures during evolution. More disperse pattern in lower vertebrates becomes specifically concentrated in distinct structures of higher vertebrates. Especially enriched in GT1b are motor neurons of human, cat and rat spinal cord, indicating specific requirement of these cells and suggest use of this animals instead of mouse as model for human diseases affecting motor-neurons.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

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