Naslov
West syndrome with periventricular leukomalacia: ten-year clinical study

Autori
Kuzmanić-Šamija, Radenka ; Rešić, Biserka ; Tomasović, Maja ; Gabrić Pandurić, Dragana ; Lozić, Bernarda ; Lozić, Marin ; Rešić, Jasminka

Izvornik
Collegium Anropologicum (0350-6134) 32 (2008), S1; 105-111

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
newborns; West syndrome; periventricular leukomalacia; MRI

Sažetak
The aim of the study was to evaluate magnetic resonance imaging (MRI) findings in infants with periventricular leukomalacia (PVL) and West syndrome (WS) and determine the neurodevelopmental outcome in children with West syndrome and PVL. Ultrasound and brain MRI were performed in 37 infants with recognized PVL. PVL was categorized according to De Vries, whereas West syndrome was categorized according to International League Against Epilepsy 1989. West syndrome in our patients developed during the first 2 years of life. The most common interictal abnormality was hypsarrhythmia. All, exept two patients, had delayed development and various degrees of mental retardation. The most characteristic neuroimaging findings were major reduction in cerebral cortical gray matter volume, reduction in the volume of brain myelin, and delayed myelination. These findings may explain the anatomical association between the West syndrome onset and PVL and intellectual and cognitive deficit in premature infants with PVL.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA