Naslov
Serum selenium concentration in patients with liver cirrhosis and hepatocellular carcinoma

Autori
Buljevac, Mladen ; Romić, Željko ; Vucelić, Boris ; Banić, Marko ; Krznarić, Željko ; Pleško, Sanja

Izvornik
Acta Medica Croatica (1330-0164) 50 (1996); 11-14

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
selenium in serum; liver cirrhosis; liver cirrhosis and hepatocellular carcinoma

Sažetak
The aim of the study was to investigate the serum selenium concentration in patients with liver cirrhosis and hepatocellular carcinoma. A total of 59 patients, 49 with liver cirrhosis and 10 with liver cirrhosis and coexistent hepatocellular carcinoma, as well as 202 healthy volunteers entered the study. In the patients with liver cirrhosis and in those with liver cirrhosis and coexistent hepatocellular carcinoma, serum selenium concentrations were significantly lower (39.28+/-13.99 and 42.00+/-10.59 g/L, respectivly), when compared to the group of healthy volunteers (66.79+/-9.13 g/L)(p<0.001). There was no significant difference in serum selenium concentrations between the two patient groups. In the group of patients with liver cirrhosis positive correlation was found between serum and albumin concentrations, and negative correlation between serum selenium and billirubin (p<0.05 and p<0.01, respectively). There was no correlation of serum selenium concentration with fibrinogen and prothrombin time. Results of the study suggested the possible important nutritive and protective role of selenium in the patients with liver cirrhosis and coexistent hepatocellular carcinoma, as well as the potential need of selenium supplementation in these patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA