Naslov
Synthesis and characterization of Cu(II) complexes with amino acid substituted di(2-pyridyl) amine ligands

Autori
Kirin, Srećko I. ; Yennawar, Hemant P. ; Williams, Mary Elizabeth

Izvornik
European Journal of Inorganic Chemistry (1434-1948) (2007), 23; 3686-3694

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
bioconjugates; bioinorganic chemistry; copper complexes; di(2-pyridyl)amine

Sažetak
The two-step syntheses of the substituted di(2-pyridyl)amine ligands (dpa), dpa-CH2CO2H (1) and dpa-PhCO2H (2), are described. Ligands 1 and 2 are successfully coupled to the amino acid phenylalanine, yielding the derivatives 4 and 6, respectively. Four CuII(dpa)2 complexes, [Cu(dpa-CH2CO2tBu)2(NO3)2] (3Cu), [Cu(dpa-CH2CO-PheOMe)2(H2O)2](NO3)2· ; 2MeOH (4Cu), [Cu(dpa-PhCO2Me)2 (MeOH)2](ClO4)2 (5Cu) and [Cu(dpa-PhCO-PheOMe)2(ClO4)2] (6Cu) have been prepared and characterized, including their single crystal X-ray structures. Fluorescence emission at UV (for 3 and 4) or blue (for 5 and 6) wavelengths of the free ligands is preserved in the corresponding Cu complexes, although with lower intensity. X-band EPR spectra of 4Cu and 6Cu both revealed one axial CuII signal with hyperfine and superhyperfine splittings. Complexes 4Cu and 6Cu are chiral inorganic complexes with amino acid bioconjugates that may serve as nucleoside analogs in modified peptide nucleic acids (PNA).

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA