Naslov
Plasma homocysteine and blood lipids in patients with coronary atherosclerosis

Autori
Lovrić, Mila ; Zrinski-Topić, Renata ; Skodlar, Jasna ; Maradin, Miljenka ; Stavljenić-Rukavina, Ana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Clinical Chemistry and Laboratory Medicine / - , 1999

Skup
17th International and 13th European Congress of Clinical Chemistry and Laboratory Medicine 1st International Congress of Clinical Molecular Biology (CMB)

Mjesto i datum
Firenca, Italija, 06.06.1999. - 11.06.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
homocysteine; lipids; atherosclerosis

Sažetak
Most clinical and epidemiologic studies on homocysteine and vascular disease have suggested a role of homocysteine in atherogenesis. Homocysteine is an intermediate sulphydryl amino acid formed during the conversion of metionine to cysteine. In this study total homocysteine and total cholesterol, HDL and LDL cholesterol were measured in 213 patients with established coronary atherosclerosis. Total homocysteine was measured by stable isotope dilution mass spectrometry method and total cholesterol, HDL and LDL cholesterol by standard biochemical methods. Results of measurements were (X ą SD): total homocysteine 13.15 ą 4.27 mmol/L, total cholesterol 5.77 ą 1.36 mmol/L, HDL cholesterol 0.95 ą 0.28 mmol/L and LDL cholesterol 3.91 ą 1.24 mmol/L. Results out of reference recommended range were obtained for homocysteine in 29.7 %, total cholesterol in 65.7%, HDL cholesterol in 84.5 % and LDL cholesterol in 41.7% patients. There was no statisticaly significant correlation between homocysteine and other parameters. Higher percentage of data out of reference recommended range was observed for blood lipids than for homocisteine. These results may indicate relative independence of homocysteine and blood lipids in the development of atherosclerosis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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