Naslov
CD21-CD23 ligand pair expression in children with allergic asthma

Autori
Rabatić, Sabina ; Gagro, Alenka ; Medar-Lasić, Maja

Izvornik
Clinical and Experimental Immunology (0009-9104) 94 (1993), 2; 337-340

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
allergic children; IgE regulation; CD21; CD23

Sažetak
The CD23 antigen, a low affinity receptor for IgE, was recently shown to interact with another ligand, CD21, and the pairing of these molecules is important in T cell-B cell interaction and control of IgE production. Here, we analysed the expression of CD21 and CD23 on CD4+ and CD20+ lymphocytes in 25 allergic children and 12 age-matched non-allergic controls. Both the percentage (P < 0.01) and the absolute number (P < 0.001) of CD23+ cells were increased in allergic children. There was no difference of CD21+ cells. Double positive CD4+ CD23+ cells (2.5%) were only detected in one patient, in others all CD23 being expressed on B cells. The CD21 antigen was expressed only on B cells. Furthermore, allergic children had an increased mean fluorescence intensity of both the CD21 (P < 0.001) and the CD23 (P < 0.001) receptor. To analyse the possible difference in B cell subsets expressing CD21 and CD23 antigens, three-colour fluorescence analysis was performed. In allergic children the subset of CD20+ CD21- cells expressed more CD23 than in controls (P < 0.001). These results may mean an impaired expression and possibly regulation of CD21-CD23 interaction in allergic conditions.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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