Naslov
The expression of Na+-independent sulfate transporter Sat-1 in rat proximal tubules exhibits male-dominant gender differences

Autori
Brzica, Hrvoje

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
Gottinger Transporttage 2007

Mjesto i datum
Göttingen, Njemačka, 10.11.2007. - 11.11.2007

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
sulfate transporter; sex differences; sex hormones

Sažetak
Sat-1 is the Na+-independent anion exchanger with 12 transmembrane domains and 3 potential glycosylation sites. Functionally, it exchanges sulfate for oxalate or bicarbonate. In rats, the protein has been localized to the basolateral membrane of proximal tubule S1, S2 and S3 segments, and to the sinusoidal membrane of liver cells. Gender differences were recently observed for the expression of Sat-1 mRNA in the rat kidney using the microarray chip (Sabolić et al., Eur. J. Physiol. 455: 397-429, 2007) ; the expression in males was 50% higher then in females. The aim of the present study was to verify gender differences in the expression of Sat-1 protein in the rat kidney, and to test if similar phenomenon exists in the liver.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA