Naslov
Toward the Structure of Dynamic Membrane-Anchored Actin Networks: An Approach Using Cryo-Electron Tomography
(Toward the Structure of Dynamic Membrane- Anchored Actin Networks: An Approach Using Cryo-Electron Tomography)

Autori
Gerisch, G. ; Weber, Igor

Izvornik
Cell Adhesion & Migration (1933-6918) 1 (2007), 3; 145-148

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
actin network ; cytoskeleton ; Dictyostelium ; electron tomography ; filopodia ; membrane bending

Sažetak
In the cortex of a motile cell, membrane- anchored actin filaments assemble into structures of varying shape and function. Filopodia are distinguished by a core of bundled actin filaments within finger-like extensions of the membrane. In a recent paper by Medalia et al., cryo-electron tomography has been used to reconstruct, from filopodia of Dictyostelium cells, the 3-dimensional organization of actin filaments in connection with the plasma membrane. A special arrangement of short filaments converging toward the filopod's tip has been called a "terminal cone". In this region force is applied for protrusion of the membrane. Here we discuss actin organization in the filopodia of Dictyostelium in the light of current views on forces that are generated by polymerizing actin filaments, and on the resistance of membranes against deformation that counteracts these forces.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

Napomena
Radi se o novom časopisu izdavača Landes
Bioscience.

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