Naslov
Antioxidant pretreatment and reduced arterial endothelial dysfunction after diving

Autori
Obad, Ante ; Valić, Zoran ; Palada, Ivan ; Brubakk, O. Alf ; Modun, Darko ; Dujić, Željko

Izvornik
Aviation, Space, and Environmental Medicine (0095-6562) 78 (2007), 12; 1114-1120

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
diving; endothelial function; gas bubbles; antioxidants

Sažetak
We have recently shown that single air dive leads to acute arterial vasodilation and impairment of endothelium-dependent vasodilatation in humans. Additionally we have found that pre-dive antioxidants at the upper recommended daily allowance (RDA) limit partially prevented some of the negative effects of the dive. Thus, in this study we prospectively evaluated the effect of long-term antioxidants at lower RDA dose on arterial endothelial function. Eight professional male divers performed an open sea air dive to 30 meters of sea water. Before and after dives brachial artery flow-mediated dilation (FMD) was assessed. The first dive without antioxidants caused significant brachial arterial diameter increase from 3.85&plusmn ; ; ; 0.55 to 4.04&plusmn ; ; ; 0.5 mm and a significant reduction of FMD from 7.6&plusmn ; ; ; 2.7 to 2.8&plusmn ; ; ; 2.1%. The second dive with antioxidants showed unchanged arterial diameter and significant reduction of FMD from 8.11&plusmn ; ; ; 2.4 to 6.8&plusmn ; ; ; 1.4%. The FMD reduction was significantly smaller with antioxidants. Vascular smooth muscle function, assessed by nitroglycerine (endothelium-independent dilation), was unaffected by diving. This study shows that long term antioxidants treatment at lower RDA dose ending 3-4 hours before dive reduces the endothelial dysfunction in divers. Since the scuba dive was of the depth and duration similar to those practiced by numerous recreational divers, this study raises the possibility of routine pre-dive supplementation with antioxidants.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA