Pregled bibliografske jedinice broj: 308947
The influence of daylight exposure on platelet 5-HT levels in patients with major depression and schizophrenia
The influence of daylight exposure on platelet 5-HT levels in patients with major depression and schizophrenia // Journal of Photochemistry and Photobiology. B, 89 (2007), 2/3; 63-69 doi:10.1016/j.jphotobiol.2007.09.002 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 308947 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
The influence of daylight exposure on platelet 5-HT levels in patients with major depression and schizophrenia
Autori
Ljubičić, Đulijano ; Stipčević, Tamara ; Pivac, Nela ; Jakovljević, Miro ; Muck-Šeler, Dorotea
Izvornik
Journal of Photochemistry and Photobiology. B (1011-1344) 89
(2007), 2/3;
63-69
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
periods of daylight exposure; platelet 5-HT; schizophrenia; depression
Sažetak
Platelet serotonin (5-HT) can be used as a limited, peripheral model for the central 5-HT synaptosomes. Altered platelet 5-HT concentrations have been associated with psychiatric disorders like depression and schizophrenia. The aim of the present study was to compare platelet 5-HT concentrations during long, medium and short period of natural daylight exposure in a large number of medication-free male and female schizophrenic and depressed patients and sex-matched healthy controls. Platelet 5-HT concentration was determined spectrofluorimetrically in 240 (97 female, 143 male) schizophrenic and 258 (153 female, 105 male) nonpsychotic, nonsuicidal depressed medication-free patients and 328 (149 women, 179 men) healthy subjects during periods with short (<12), long (>12) and medium (average 12) hours of the natural daylight. Platelet 5-HT concentration was significantly lower in women compared to men in all groups. Healthy male subjects had significantly higher (p=0.011) platelet 5-HT concentrations during long compared to medium period. There were no significant differences (p>0.05) in platelet 5-HT concentration between different periods in healthy women. The significant increase in platelet 5-HT values were found in female (p=0.01) and male (p=0.029) depressed patients during long compared to short period. There were no significant associations between platelet 5-HT concentrations and different periods in both male and female schizophrenic patients. The results indicate the sex-related differences in the serotonergic system. The alterations of platelet 5-HT concentrations, observed across period with different durations of daylight exposure, point to a direct or indirect effect of light on peripheral 5-HT system that could be related to different sensitivity of the pineal gland to light and/or melatonin influence on 5-HT metabolism.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
062-0982522-0069 - Klinički i biološki pokazatelji generaliziranog anksioznog i paničnog poremećaja (Ljubičić, Đulijano, MZOS ) ( CroRIS)
098-0982522-2455 - Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja (Pivac, Nela, MZOS ) ( CroRIS)
098-0982522-2457 - Farmakogenomika i proteomika serotoninskog i kateholaminskog sustava (Muck-Šeler, Dorotea, MZOS ) ( CroRIS)
108-1080037-0323 - Multidimenzionalna analiza bioloških pokazatelja u duševnim poremećajima (Jakovljević, Miro, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb
Profili:
Đulijano Ljubičić
(autor)
Tamara Stipčević
(autor)
Dorotea Muck-Šeler
(autor)
Miro Jakovljević
(autor)
Nela Pivac
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE