Naslov
Effect of steroids on the frequency of regulatory T cells and expression of FOXP3 in a patient with systemic lupus erythematosus : a two-year follow-up

Autori
Cepika, Alma-Martina ; Marinić, Igor ; Morović-Vergles, Jadranka ; Soldo-Jureša, Dragica ; Gagro, Alenka

Izvornik
Lupus (0961-2033) 16 (2007), 5; 374-377

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo uredniku, znanstveni

Ključne riječi
glucocorticoid therapy; systemic lupus erythematosus; regulatory T cells; Foxp3

Sažetak
Regulatory T cells (Tregs) maintain peripheral tolerance by restricting the activity of nearby immunocytes. The loss of tolerance can induce development of autoimmune diseases, such as systemic lupus erythematosus (SLE). It has previously been shown that SLE patients have lower levels of Tregs than controls. Herein we show that glucocorticoid therapy in a newly diagnosed SLE patient was accompanied with the increase in the percentage of CD4+CD25+Foxp3 T cells to the higher levels than in healthy controls. No effect of the therapy was observed on the percentage of CD4+CD25+ T cells. The observed difference in correlation of the CD4+CD25+ and CD4+CD25+Foxp3+ T cells levels with disease onset in a patient receiving steroids emphasized the importance of critical evaluation of Treg phenotype and their role in the control of SLE.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

Napomena
A letter to the editor about the effect of steroids on the frequency of regulatory T cells and expression of FOXP3 in a patient with systemic lupus erythematosus is presented.

POVEZANOST RADA