Naslov
Antioxidant properties of ganglioside micelles

Autori
Gavella, Mirjana ; Kveder, Marina ; Lipovac, Vaskresenija ; Jurašin, Darija ; Filipović-Vinceković, Nada

Izvornik
Free Radical Research (1071-5762) 41 (2007), 10; 1143-1150

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Gangliosides ; micelles ; free radicals ; antioxidants ; electron paramagnetic resonance ; Zeta potential

Sažetak
Antioxidant activity of gangliosides GM1 and GT1b in the Fenton type of reaction was investigated by EPR spectroscopy using DMPO as a spin trap. Hydroxyl radical spin adduct signal intensity was significantly reduced in the presence of gangliosides at their micellar concentrations. Mean micellar hydrodynamic diameter was not changed, whereas significant changes in negative Zeta potential values were observed as evidenced by Zetasizer Nano ZS. This study showed that the primary mode of ganglioside action was not due to direct scavenging of OH· , but rather to the inhibition of hydroxyl radical formation. This phenomenon is related to the ability of ganglioside micelles to bind oppositely charged ferrous ions, thus reducing their concentration and consequently inhibiting OH· formation.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Kemija, Biologija

POVEZANOST RADA