Naslov
Prediktivna vrijednost fosforiliranih tau proteina u cerebrospinalnoj tekućini pri postavljanju dijagnoze Alzheimerove bolesti u osoba s blagim kognitivnim oštećenjem
(CSF phosphorylated tau proteins as predictors of Alzheimer's disease in subjects with mild cognitive impairment)

Autori
Šimić, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Periodicum biologorum 109 (Suppl. 2) / Banfić, H ; Boban, M ; Francetić, I ; Klarica, M ; Mueck-Šeler, D. ; Pivac, N ; Sabolić, I ; Tvrdeić, A ; Župan, G - Zagreb : Hrvatsko prirodoslovno društvo, 2007, 43-43

Skup
5th Croatian Congress of Pharmacology and 2nd Congress of Croatian Physiological Society

Mjesto i datum
Osijek, Hrvatska, 19.09.2007. - 22.09.2007

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
Alzheimerova bolest; cerebrospinalna tekućina; rana dijagnostika; tau proteini
(Alzheimer's disease; cerebrospinal fluid; early diagnostics; tau proteins)

Sažetak
Major efforts are under way to define reliable biomarkers of Alzheimer’ s disease (AD). With the advent of new drugs such as gamma-secretase inhibitors, early detection of elderly subjects with mild cognitive impairment (MCI) who are destined to develop AD is becoming increasingly important. Highly significant increases of hyperphosporylated tau proteins in cerebrospinal fluid (CSF) have been recently reported in AD patients compared to controls by several independent groups, including ours. These findings support the notion that CSF phosphorylated tau proteins may be useful biomarkers in the early identification of AD in MCI subjects.

Izvorni jezik
Hrvatski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Psihologija

POVEZANOST RADA