Pregled bibliografske jedinice broj: 304741
Plasma parathyroid hormone-related peptide and bone metabolism in periparturient dairy cows
Plasma parathyroid hormone-related peptide and bone metabolism in periparturient dairy cows // Acta Veterinaria Hungarica, 56 (2008), 2; 235-244 doi:10.1556/AVet.56.2008.2.11 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 304741 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Plasma parathyroid hormone-related peptide and bone metabolism in periparturient dairy cows
Autori
Filipović, Natalija ; Stojević, Zvonko ; Zdelar-Tuk, Maja ; Kušec, Vesna
Izvornik
Acta Veterinaria Hungarica (0236-6290) 56
(2008), 2;
235-244
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
dairy cow; lactation; PTHrP; bone remodelling markers
Sažetak
The first weeks of lactation in dairy cows are characterised by elevated bone resorption. The connection between lactation and bone metabolism is still discussed. In this work, changes in the concentration of plasma parathyroid hormone-related peptide (PTHrP) and markers of bone metabolism were studied in Holstein cows and heifers in the dry period and early lactation to determine the role of PTHrP in the relationship between the rate of bone remodelling and the onset of lactation in dairy cows. Blood samples of were taken 14 days before calving(“ D-14” , n=23) and than on day 10 (“ D+10” , n=21) and day 30 after calving (“ D+30” , n=23). Using enzyme immunoassay (EIA), the concentrations of PTHrP, parathyroid hormone (PTH), carboxyterminal cross-linked telopeptide of type I collagen (CTX) and oestradiol and the activity of bone specific alkaline phosphatase (BSALP) were determined. The results showed a statistically significant increase in plasma PTHrP (p<0.005) and CTX (p<0.0001) in cows on "D+10” as compared to “ D-14” and CTX on “ D+30” compared to “ D-14” (p<0.0001). Significant negative correlations were found between the concentrations of PTHrP and estradiol (r = -0.29, p<0.05) and those of CTX and estradiol (r = -0.54, p<0.0001). In nonpregnant heifers (n=6), the concentration of CTX and the activity of BSALP were significantly higher(p<0.0001) then in dry cows. The observed increments of PTHrP and bone resorption after parturition reveal adaptations of bone metabolism to lactation in dairy cows.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti, Veterinarska medicina
POVEZANOST RADA
Projekti:
053-0531854-1850 - Hranidbeno metaboličke osnove podizanja kvalitete animalnih namirnica (Poljičak Milas, Nina, MZOS ) ( CroRIS)
053-1080229-2104 - Metabolizam minerala u domaćih životinja u uvjetima visoke proizvodnje i stresa (Stojević, Zvonko, MZOS ) ( CroRIS)
214-1080229-0163 - Zajednička molekularna osnova etiopatogeneza koštanih poremećaja u ljudi (Kušec, Vesna, MZOS ) ( CroRIS)
Ustanove:
Veterinarski fakultet, Zagreb,
Klinički bolnički centar Zagreb
Profili:
Zvonko Stojević
(autor)
Maja Zdelar-Tuk
(autor)
Vesna Kušec
(autor)
Natalija Filipović
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
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