Naslov
Somatosensory evoked potentials in wistar rats: a comparative analysis in relation to age

Autori
Bjegović, Milica ; Išgum, Velimir ; Slijepčević, Milivoj

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Proceedings 10th International Symposium on Biomedical Engineering '94 / Štambuk-Boršić, Neda ; Magjarević, Ratko - Zagreb : Hrvatsko društvo za biomedicinsko inženjerstvo i medicinsku fiziku ; Hrvatsko društvo za komunikacije, računarstvo, elektroniku, mjerenja I automatiku (KoREMA), 1994, 12-15

ISBN
953-6037-06-8

Skup
10th International Symposium on Biomedical Engineering '94

Mjesto i datum
Zagreb, Hrvatska, 24.11.1994. - 26.11.1994

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
somatosensory evoked potentials; aged rats

Sažetak
Short latency somatosensory evoked potentials (SEPs) as the response to subcutaneous electrical stimulation of peripheral nerves were investigated in healthy male Wistar rats of different age. Averaged SEPs evoked in aging rats (12 months old ) were compared to those of 16 and 18 months. SEPs consisted of early negative components (Nl, N2, N3), part of far-field potential proceeding to NPN wave complex. In transiently anaesthetized rats they occurred 2.40 to 25 ms from the stimulus onset Significant differences of SEPs in the examined age groups as measured in terms of latencies and the amplitudes of the registered waves 1vere found in both early and later part of the SEP. Statistically significant prolongation (48.7 %) of Nl potential accompanied by the amplitude decrease (53.0 %) obtained in our experiments on the 18 months old rats might lead us to the assumption of the prolonged peripheral conduction time correlated to aging. On the other hand the latency prolongation of the later N peaks, as well as the increased duration of NPN wave in aged rats were accompanied by the statistically significant increase of the amplitudes (523 %). The presented data obtained in our study on aging rats are consistent with the respect in human studies.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Kliničke medicinske znanosti

POVEZANOST RADA