Naslov
Evoked-potentials in diabetic syndrome of rats before and after 2 months of methadone treatment
(Evoked potentials in diabetic syndrome of rats before and after two months of methadone treatment)

Autori
Bjegović, Milica ; Išgum, Velimir ; Slijepčević, Milivoj

Izvornik
Croatica Chemica Acta (0011-1643) 68 (1995), 3; 521-531

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
somatosensory evoked potentials ; methadone ; diabetes

Sažetak
The effect of two months treatment with methadone (0.87 mg/kg per os, daily) on the somatosensory evoked potentials (SEPs) in female control and diabetic rats were studied. Diabetes was induced by alloxan monohydrate (65 mg/kg i.v.). SEPs obtained after electrical stimulation of the contralateral forepaw and recorded from the scalp, by an non invasive method, showed high reproducibility. Prolonged latency (156%) and a marked amplitude enhancement (371%) characterized the mid-latency SEPs following 64 days methadone treatment of healthy rats. Experimental diabetes induced significant alteration of both parameters ; amplitude decrease of earlier components (N1, P2) and delayed latency of later ones (P3). Two months methadone treatment of diabetic rats not only leads to the recovery but also augmented P2 (P25) amplitude (225%). It was concluded that no essential differences exist in the methadone effect on control (healthy) and diabetic Wistar female rats. [References: 21]

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti

POVEZANOST RADA