Naslov
A computerized method of somatosensory evoked potentials monitoring: III. Waveform shapes before and during glucose tolerance test in healthy male and female rats of advanced age

Autori
Bjegović, Milica ; Išgum, Velimir ; Slijepčević, Milivoj

Izvornik
Periodicum biologorum (0031-5362) 98 (1996), 2; 231-236

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Glucose tolerance test ; Noninvasive method ; Rats ; Somatosensory evoked potentials

Sažetak
Background and purpose: It has been shown that SEPs are significantly changed in diabetics having disturbed glucose tolerance test (GTT) expressed as diminished K-values. Changed GTT is a precise method for diagnosing the state of 'prediabetes' in which diabetic symptoms as hyperglycaemia and glycosuria are absent. Hence, it would be of great importance to monitor the SEPs in correlation with GTT. In the present work wave shapes in healthy and very old rats before and after glucose loading were studied. Material and methods: Wistar female and male rats aged 22-24 months were used. SEPs were followed before and after the glucose loading (1.0 g/kg of b.w., i.v.) and recorded after 10, 25, 55 and 115 minutes. Results: SEPs in old female and male rats before the glucose loading were not significantly different in fundamental peak latencies, as well as amplitudes except in the earliest waves. However after the glucose loading we observed some differences in several fundamental peaks of SEPs, in relation to time. Although latency of peak P12 was shortened till the 25th min, there was no difference at the 55th min. Other peak latencies such as P20, P29, N30 and P32 were prolonged in time and returned to control values at the 55th min. P20-N25 interpeak latency was significantly decreased (52%) at the 25th min. N25-P29 peak to peak amplitude was significantly increased at the 25th min after glucose loading (163.1%). Conclusion: Observed changes of most wave components for latencies and amplitudes are moving in the same direction continously in time. All of them showed recovery, some after 25 min, while others in the 55th or the 115th min after the glucose loading.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA