Pregled bibliografske jedinice broj: 303538
Comparative analysis of cognitive evoked potentials and motor reaction in the healthy subjects and patients on different antiepileptic therapies
Comparative analysis of cognitive evoked potentials and motor reaction in the healthy subjects and patients on different antiepileptic therapies // Neurologia Croatica / Hajnšek, S. ; Išgum, V. ; Mitrović, Z. (ur.).
Zagreb: Neurološka klinika KBC Zagreb, 2004. str. 75-75 (predavanje, domaća recenzija, sažetak, znanstveni)
CROSBI ID: 303538 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Comparative analysis of cognitive evoked potentials and motor reaction in the healthy subjects and patients on different antiepileptic therapies
Autori
Nesek-Mađarić, Vesna ; Išgum, Velimir
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Neurologia Croatica
/ Hajnšek, S. ; Išgum, V. ; Mitrović, Z. - Zagreb : Neurološka klinika KBC Zagreb, 2004, 75-75
Skup
II. hrvatski neurofiziološki kongres
Mjesto i datum
Dubrovnik, Hrvatska, 21.09.2004. - 26.09.2004
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Domaća recenzija
Ključne riječi
cognitive evoked potentials; reaction time; epilepsy
Sažetak
It is well known that antiepileptic drugs have side effects on cognitive and behavioral functioning of treated patients. Our goal was to investigate their influence on cognitive evoked potentials peak latencies and patient reaction times to target stimuli for two different, acoustic and visual, stimulating paradigms. A control group of healthy subjects and two group of epileptic patients treated with antiepileptic drugs (carbomazepine, phenobarbitone) were compared. Group 1 patients had subtherapeutic and group 2 patients therapeutic drug concentration in the blood. Group 3 patients were treated with carbomazepine in a therapeutic dose for nonepileptic reason. The N1, P2, N2, P3a and P3b peak latencies as well as reaction time to the same target stimuli were analyzed. The results obtained for acoustic and visual stimulating paradigm did not show any significant differences suggesting that the simple acoustic paradigm could be used for screening. The hypothesis that antiepileptic drugs influence the parameters of cognitive evoked potentials when used as polytherapy was confirmed. The reaction time measured in the same group of subjects showed statistically significant, however, the effect on the reaction time of treated patients was even more pronounced. Study results were consistent with our thesis that this suitable neurophysiologic method could be successfully used as a screening method to asses the cognitive and motor state of antiepileptic treated patients.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Klinički bolnički centar Zagreb
