Naslov
Interaction of novel benzimidazole derivatives with double stranded DNA/RNA in aqueous media

Autori
Hranjec, Marijana ; Piantanida, Ivo ; Karminski-Zamola, Grace

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
ESOC 15 Abstracts / Guiry, Pat ; Mooney, Ann - Dublin, 2007, 205-205

Skup
The 15th European Symposium on Organic Chemistry

Mjesto i datum
Dublin, Irska, 08.07.2007. - 13.07.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
benzimidazoli; amidini; interakcija s DNA/RNA
(benzimidazoles; amidines; interaction with DNA/RNA)

Sažetak
Substituted benzimidazoles and their fused cyclic derivatives as well as heteroaromatic amidines have attracted considerable attention from medicinal and synthetic organic chemists because of the wide range of biological activities displayed by this class of compounds. Interaction of aromatic compounds with double stranded (ds) polynucleotides is of paramount significance for many biologically and medicinally important interactions. [1, 2] Our previous results pointed toward intriguing interactions of benzimidazole, thiophene and furane derivatives with ds-DNA.[3, 4] Here we present the study of interactions of novel biologically active acyclic and cyclic heteroaromaticaly substituted benzimidazole derivatives 1-5 (Figure 1.) with ds-DNA and RNA (polyA-polyU and polyG-polyC) by UV/Vis, f1uorimetric and CD titrations and thermal denaturation experiments. The obtained results revealed that even minor changes in structure of acyclic compounds 1-3, as well as of cyclic 4, 5 have strong influence on dominant type of binding to ds-DNA and RNA. Figure 1. References: [1].M. Demeunyvnk, C. Baily, W. D. Wilson ; DNA and RNA binders, Wiley-VCH, Weinheim, 2002. [2]. K. Li, G. Xiao, T. Rigl, A. Kumar, D. W. Boykin, W. D. Wilson, In Structure, Motion, Interaction and Expression of Biological Macromolecules, (Eds. ; R.H. Sarma, M.H. Sarma), Adenine Press, 1998. [3]. K. Starčević, G. Karminski-Zamola, I. Piantanida, M. Žinić, L. Šuman, M. Kralj, „ Photoinduced Switch of a DNA/RNA Inactive Molecule into a Classical Intercalator“ J. Am. Chem. Soc., 127, 1074-1075, 2005 ; [4]. I. Jarak, M. Kralj, L. Šuman, J. Dogan , I. Piantanida, M. Žinić, K. Pavelić, G. Karminski- Zamola, „ Novel Cyano-and N-isopropylamidino-Substituted Derivatives of Benzo[b]thiophene-2-carboxanilides and Benzo[b]thieno[2, 3-c]quinolones: Synthesis, Photochemical Synthesis, Crystal Structure Determination and Antitumor Evaluation. Part 2.“ J. Med. Chem. 48, 2346-2360, 2005.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA