Synthesis, Antiviral and Antitumor Activity of 2- substituted-5-amidino-benzimidazoles

Starčević, Kristina; Kralj, Marijeta; Ester, Katja; Sabol, Ivan; Grce, Magdalena; Pavelić, Krešimir; Karminski-Zamola, Grace

doi:10.1016/j.bmc.2007.04.032

Pregled bibliografske jedinice broj: 295821

Synthesis, Antiviral and Antitumor Activity of 2- substituted-5-amidino-benzimidazoles

Starčević, Kristina; Kralj, Marijeta; Ester, Katja; Sabol, Ivan; Grce, Magdalena; Pavelić, Krešimir; Karminski-Zamola, Grace

Synthesis, Antiviral and Antitumor Activity of 2- substituted-5-amidino-benzimidazoles // Bioorganic & medicinal chemistry, 15 (2007), 13; 4419-4426 doi:10.1016/j.bmc.2007.04.032 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 295821 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Synthesis, Antiviral and Antitumor Activity of 2- substituted-5-amidino-benzimidazoles

Autori
Starčević, Kristina ; Kralj, Marijeta ; Ester, Katja ; Sabol, Ivan ; Grce, Magdalena ; Pavelić, Krešimir ; Karminski-Zamola, Grace

Izvornik
Bioorganic & medicinal chemistry (0968-0896) 15 (2007), 13; 4419-4426

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
benzimidazoles; amidines; N-methylpyrrole; pyridine; imidazole; antiviral activity; antitumor activity

Sažetak
We have prepared a set of heterocyclic benzimidazole derivatives bearing amidino substituents at C-5 of benzimidazole ring, by introducing various heterocyclic nuclei (pyridine, N-methyl-pyrrole or imidazole) at C-2, and evaluated their antitumor and antiviral activities. The most pronounced antiproliferative activity was shown with compounds 6 and 9, having imidazolinylamidino-substituent. Interestingly, all compounds show remarkable selectivity towards breast cancer cell line MCF-7. The most distinct and selective antiviral activity towards Coxackieviruses and Echoviruses was observed with compounds having pyridine ring at C-2. Especially interesting was fairly strong activity of the compounds 4 and 8 toward adenoviruses, which could be considered as leads against adenoviral replication.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti

POVEZANOST RADA

Projekti:
098-0982464-2510 - Promijenjeno stanje DNA-metilacije u HPV-povezanim oštećenjima (Grce, Magdalena, MZOS ) ( CroRIS)
098-0982464-2514 - Uloga različitih mehanizama odgovora stanica na terapiju oštećenjem DNA (Kralj, Marijeta, MZOS ) ( CroRIS)
125-0982464-1356 - Novi heterocikli kao antitumorski i antivirusni (pametni) lijekovi (Hranjec, Marijana, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Profili:

Ivan Sabol (autor)