Naslov
Identification and distribution of CD+ T-cell subsets in porcine gut following experimental infection with F4ac+ enterotoxigenic Escherichia coli (ETEC) or non-ETEC strains

Autori
Valpotić, Ivo ; Vijtiuk, Nada ; Trutin-Ostović, Karmen ; Casey, Thomas A ; Dean-Nystrom, Eveliyn A. ; Lacković, Gordana

Izvornik
Regional immunology (0896-0623) 6 (1994); 387-390

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
CD+ T cell subsets; porcine gut; infection; ETEC

Sažetak
Distinct patterns of cluster differentuiation (CD) antigen expression on T lymphocyte subsets and distribution of CD+ T cells in jejunal lamina propria (LP), Peyer´s patches (PP) and ileal mesenteric lymph node (MLN) have been correlated with diarrheal disease or lo9cal protection due to enterotoxigenic Escherichia coli (ETEC)/non-ETEC infection in 4-week-old pigs.An increase of CD2a+, CD8a+ in LP and SWC1a+ cells in MLN of pigs infected with ETEC strain M1823 was observed. Non_ETEC strain stimulated a strong proliferation of cytolitic CD8a+ cells in LP.In 2407-inoculated pigs marked infiltration of CD8a+ cells were demonstrated in LP/PP and paracortex of MLN. Recombinant nontoxigenic strain 2407 seems to be a good source of protective antigen for development of a safe and effective live oral vaccine against postweaning colibacillosis in swine.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

Napomena
Rad je kao poster prezentiran na skupu 2nd Alps-Adria Immunology and Allergology Meeting, održanom od 26.-29.09.1994., Opatija, Hrvatska.

POVEZANOST RADA